Irrigation Solutions in Head and Neck Cancer Surgery

Lodhia, Kunal A.; Dale, Oliver; Winter, Stuart C

doi:10.1177/0003489414543101

Cited by 5 publications

(6 citation statements)

References 5 publications

(6 reference statements)

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“…For head and neck cancer surgery, a preclinical efficacy study found that sterile water demonstrated a modest effect on cell survival, whereas 0.9% saline had no effect. 35 The addition of chemical adjuvants, such as 3% hydrogen peroxide, 0.05% chlorhexidine gluconate, and 0.3% povidone iodine solutions may reduce the burden of residual tumor cells. 36 However, further studies in vivo or clinical studies are required to assess its safety and efficacy.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature

Weng,

Kwan,

Chen

et al. 2024

Head & Neck

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BackgroundExtrathyroid implantation or dissemination of thyroid tissue secondary to a thyroid procedure is rare. Most of these belonged to thyroid carcinoma with metastatic potential and uncommon for benign pathologies.MethodsWe report the case of a 31‐year‐old female who was identified to have multiple subcutaneous implantation of thyroid tissue 5 years after transoral endoscopic thyroidectomy vestibular approach. A comprehensive literature search on implantation of thyroid tissue secondary to thyroid procedures was performed.ResultsAccidental tearing of the capsule during previous surgery may lead to the subcutaneous implantation. Through literature review, a total 29 articles with 47 patients were identified. 33.3% were benign lesions, and implantation was mostly secondary to fine needle aspiration biopsy (46.5%).ConclusionsSubcutaneous or port site implantation after endoscopic thyroid surgery may occur in benign thyroid pathologies and therefore, oncologic principles must be strictly followed during surgery regardless of its histopathological nature.

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Section: Discussionmentioning

confidence: 99%

Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature

Weng,

Kwan,

Chen

et al. 2024

Head & Neck

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“…However, the saline washout is volume dependent and should be used copiously [20]. Furthermore, copious irrigation can keep the wound cavity clean and prevent infection, especially in aerodigestive tract [21,22]. Using this conservative treatment modality, the deciduous teeth and IAN can be preserved and the risk of recurrence as well as infection can be decreased.…”

Section: Discussionmentioning

confidence: 99%

Conservative Decompression Management with Functional Appliance in Pediatric Plexiform Ameloblastoma

Mustakim

Sodnom-Ish

et al. 2021

Applied Sciences

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Ameloblastoma is an infiltrative benign neoplasm in the mandible or maxilla that is locally aggressive with rare metastasizing capacity. This lesion is the most common tumor of the odontogenic epithelium. However, its occurrence in children is low, representing only 10–15% of all reported ameloblastoma cases. In treating such benign neoplasms in pediatric patients, the preservation of vital structures such as the inferior alveolar nerve (IAN), deciduous teeth, tooth buds, and nerves with proper post-operative management to maintain normal mandibular growth is imperative. A five-year-old boy with painless swelling and displaced teeth in the right mandible was diagnosed with plexiform ameloblastoma. Instead of a radical approach, the patient was treated conservatively using decompression and routine irrigation along with long-term follow-up. Functional appliance treatment was provided using a Frankel appliance to preserve and induce normal growth of the jaw. After eight years, there was no recurrence of the ameloblastoma, and normal mandibular growth of the patient was observed. Pediatric plexiform ameloblastoma should be treated with a conservative approach considering the preservation of important anatomic structures and further mandibular growth. Moreover, functional appliance therapy should be considered as an integral part of treatment for pediatric ameloblastoma and other tumors in children to maintain and induce normal growth of the mandible.

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“…[ 17 ] In head and neck cancer models, both the type of irrigation and type of cancer cell line contributed to efficacy. [ 18 , 19 ] These and other conflicting data suggest that multiple factors play a role with respect to the eradication of residual tumor burden, potentially related to the microenvironment and tumor cell-specific factors, such as cell adhesion properties and degree of de-differentiation.…”

Section: Discussionmentioning

confidence: 99%

Continuous saline bladder irrigation for two hours following transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer does not prevent recurrence or progression compared with intravesical Mitomycin-C

et al. 2018

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BackgroundIntravesical Mitomycin-C (MMC) following transurethral resection of bladder tumor (TURBT), while efficacious, is associated with side effects and poor utilization. Continuous saline bladder irrigation (CSBI) has been examined as an alternative. In this study we sought to compare the rates of recurrence and/or progression in patients with NMIBC who were treated with either MMC or CSBI after TURBT.MethodsWe retrospectively reviewed records of patients with NMIBC at our institution in 2012–2015. Perioperative use of MMC (40 mg in 20 mL), CSBI (two hours), or neither were recorded. Primary outcome was time to recurrence or progression. Descriptive statistics, chi-squared analysis, Kaplan-Meier survival analysis, and Cox multivariable regression analyses were performed.Results205 patients met inclusion criteria. Forty-five (22.0%) patients received CSBI, 71 (34.6%) received MMC, and 89 (43.4%) received no perioperative therapy. On survival analysis, MMC was associated with improved DFS compared with CSBI (p = 0.001) and no treatment (p = 0.0009). On multivariable analysis, high risk disease was associated with increased risk of recurrence or progression (HR 2.77, 95% CI: 1.28–6.01), whereas adjuvant therapy (HR 0.35, 95% CI: 0.20–0.59) and MMC (HR 0.43, 95% CI: 0.25–0.75) were associated with decreased risk.ConclusionsPostoperative MMC was associated with improved DFS compared with CSBI and no treatment. The DFS benefit seen with CSBI in other studies may be limited to patients receiving prolonged irrigation. New intravesical agents being evaluated may consider saline as a control given our data demonstrating that short-term CSBI is not superior to TURBT alone.

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Irrigation Solutions in Head and Neck Cancer Surgery

Abstract: These data suggest a significant difference in the cytocidal effect of commonly used irrigation solutions on head and neck cancer cells in an in vitro model.

Cited by 5 publications

References 5 publications

Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature

Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature

Conservative Decompression Management with Functional Appliance in Pediatric Plexiform Ameloblastoma

Continuous saline bladder irrigation for two hours following transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer does not prevent recurrence or progression compared with intravesical Mitomycin-C

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