Irrigation of the capsular bag using a sealed-capsule irrigation device and 5-fluorouracil

Milverton, E. J.

doi:10.1038/eye.2008.329

Cited by 5 publications

(4 citation statements)

References 4 publications

(5 reference statements)

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“…Sealed-capsule irrigation using either distilled water or 5-fluorouracil has been shown to be successful in reducing the incidence of visual axis opacification in adult eyes by killing the LECs. 142 , 143 This device may help pediatric cataract surgeons to overcome the problem of PCO, but the risk of endothelial cell loss cannot be underestimated. The development of the bag-in-the-lens technique by Tassignon et al shows promise, because by using this lens the LECs are trapped between the anterior and posterior capsules, thus reducing dramatically the rate of PCO.…”

Section: Complicationsmentioning

confidence: 99%

“…Capsule-irrigating devices customized for pediatric eyes, which will reduce the speed and severity of proliferation of LECs, or future research discovering the drugs antagonizing the effect of factors responsible for PCO are warranted. 142 , 143 Recently, the results in an animal model indicated that there was a beneficial effect on postoperative inflammation with dexamethasone-coated IOLs. 149 It is reasonable to assume that IOLs will be designed that can deliver slow-release molecules to reduce inflammation and obviate the need for topical anti-inflammatory treatment.…”

Section: Future Directionsmentioning

confidence: 99%

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Pediatric cataract: challenges and future directions

Medsinge

Nischal²

2015

OPTH

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Cataract is a significant cause of visual disability in the pediatric population worldwide and can significantly impact the neurobiological development of a child. Early diagnosis and prompt surgical intervention is critical to prevent irreversible amblyopia. Thorough ocular evaluation, including the onset, duration, and morphology of a cataract, is essential to determine the timing for surgical intervention. Detailed assessment of the general health of the child, preferably in conjunction with a pediatrician, is helpful to rule out any associated systemic condition. Although pediatric cataracts have a diverse etiology, with the majority being idiopathic, genetic counseling and molecular testing should be undertaken with the help of a genetic counselor and/or geneticist in cases of hereditary cataracts. Advancement in surgical techniques and methods of optical rehabilitation has substantially improved the functional and anatomic outcomes of pediatric cataract surgeries in recent years. However, the phenomenon of refractive growth and the process of emmetropization have continued to puzzle pediatric ophthalmologists and highlight the need for future prospective studies. Posterior capsule opacification and secondary glaucoma are still the major postoperative complications necessitating long-term surveillance in children undergoing cataract surgery early in life. Successful management of pediatric cataracts depends on individualized care and experienced teamwork. We reviewed the etiology, preoperative evaluation including biometry, choice of intraocular lens, surgical techniques, and recent developments in the field of childhood cataract.

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Section: Complicationsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Pediatric cataract: challenges and future directions

Medsinge

Nischal²

2015

OPTH

View full text Add to dashboard Cite

show abstract

“…16,17 This system allows to isolate the intracapsular space from the anterior chamber by sealing the lens capsule with a silicone disc attached to capsulorhexis edges and simultaneously to irrigate the space with different chemical agents. [7][8][9][10] From the point of view of mechanical activity, chemical methods aim at decreasing the LEC quantity or their proliferating potential. Mechanical cleaning of the capsular bag should be mentioned among other methods suppressing the number of proliferating LECs.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] However, in clinical studies there are used hypotonic properties of distilled water (DW) in relation to LECs or 5-FU inhibiting their proliferation. [7][8][9][10][11][12] Unfortunately, toxicity of the applied preparations concerns all eye structures, particularly endothelial cells, which is a marked limitation in their practical use. 11,[13][14][15] Perfect Capsule TM device (Milvella Pty Ltd) used for sealed-capsule irrigation (SCI) creates higher safety for eye structures.…”

Section: Introductionmentioning

confidence: 99%