Irreversible impairment of inhibitory neurons and nitric oxide release in the neocortex produced by low temperature and hypoxia in vitro

Fujisaki, Toshiyuki; Wakatsuki, Hidemitsu; Kudoh, Masaharu; Shibuki, Katsuei

doi:10.1016/s0168-0102(99)00023-1

Cited by 3 publications

(2 citation statements)

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“…Moreover, it is reported that excitatory pyramidal cells and inhibitory interneurons in the hippocampus are sensitive to temperature. [32,45,46] Additionally, Stephan's experiment verified that astrocytes are temperature dependent. [41] Thus, we introduce a temperature factor into the minimum model reference to Ref.…”

Section: Model and Methodsmentioning

confidence: 92%

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Effect of astrocyte on synchronization of thermosensitive neuron-astrocyte minimum system

et al. 2022

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Astrocytes have a regulatory function on the central nervous system (CNS), especially in the temperature sensitive hippocampal region. In order to explore the thermosensitive dynamic mechanism of astrocytes in CNS, we establish a neuron-astrocyte minimum system to analyze the synchronization change characteristics based on Hodgkin-Huxley model, in which a pyramidal cell and an interneuron are connected by an astrocyte. Besides, the temperature range set 0°C-40°C to juggle theoretical calculation and reality of brain environment. It is represented that the synchronization of thermosensitive neurons exhibits nonlinear behavior with change of astrocyte parameters. At temperature range of 0°C-18°C, the effects of astrocyte can provide tremendous influence to neurons in synchronization. We found existence of a value for inositol triphosphate (IP3) production rate and feedback intensities of astrocyte to neurons, which can ensure the weak synchronization of two neurons. In addition, it is revealed that the regulation of astrocyte to pyramidal cell is more sensitive than that to interneuron. Finally, it is shown that the synchronization and phase transition of neurons depend on the change of Ca2+ concentration at the temperature of weak synchronization. The results in this paper would provide some enlightenment in mechanism of cognitive dysfunction and neurological disorders with astrocytes.

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Section: Model and Methodsmentioning

confidence: 92%

“…In addition, it is verified that temperature can affect the ion conductance and ion gate channel variable in neurons. [36,[45][46][47] According to Ref. [47], the parameter ρ denotes the temperature scale factor of ion conductance in Eq.…”

Section: Model and Methodsmentioning

confidence: 99%