2020
DOI: 10.1080/1028415x.2020.1853418
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Irreversible hippocampal changes induced by high fructose diet in rats

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Cited by 17 publications
(9 citation statements)
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“…In another study, male rats that received an adolescent CAF diet were not impaired in a spatial memory task despite showing symptoms of metabolic syndrome, which were reversible by switching to standard chow [28]. Moreover, studies using a diet manipulation similar to our SUG model revealed that a high-sugar diet during adolescence led to impairments in both HPC-dependent episodic [17] and spatial memory [44] in male rats that were not reversible by dietary intervention (i.e. removing the sugar access).…”
Section: Discussionmentioning
confidence: 87%
“…In another study, male rats that received an adolescent CAF diet were not impaired in a spatial memory task despite showing symptoms of metabolic syndrome, which were reversible by switching to standard chow [28]. Moreover, studies using a diet manipulation similar to our SUG model revealed that a high-sugar diet during adolescence led to impairments in both HPC-dependent episodic [17] and spatial memory [44] in male rats that were not reversible by dietary intervention (i.e. removing the sugar access).…”
Section: Discussionmentioning
confidence: 87%
“…In another study, male rats that received an adolescent CAF diet were not impaired in a spatial memory task despite showing symptoms of metabolic syndrome, which were reversible by switching to standard chow (Gomez-Smith et al, 2016). Moreover, studies using a diet manipulation similar to our SUG model revealed that a high sugar diet during adolescence led to impairments in both HPC-dependent episodic (Noble et al, 2019) and spatial memory (Fierros-Campuzano et al, 2020) in male rats that were not reversible by dietary intervention (i.e., removing the sugar access). Compared to these findings in males, the present study overall suggests that female rats may benefit more from dietary intervention for neurocognitive impairments following early life excessive sugar consumption, despite consuming more of their total calories from the sugar beverage than males (here, the females consumed around ~33-36% of their daily energy intake from the sugar beverage whereas Noble et al found that males on the same diet consumed on average ~24% of their daily energy intake from the sugar beverage) (Noble et al, 2019).…”
Section: Discussionmentioning
confidence: 87%
“…Both sucrose- and fructose-sweetened beverages induced memory deficits in animal models [ 162 , 163 , 167 , 171 ], especially in males [ 160 ], even when exposure was restricted to 2 h per day [ 159 ]. These deficits may be quite permanent, since impairment was reported even one month after sweet solution withdrawal [ 166 ]. Similarly, short-term exposure (8 days) to a simple carbohydrate-based diet (mainly sucrose) was enough to damage HPC-dependent memory in a way comparable to a saturated HFD [ 100 ].…”
Section: High-sugar Dietmentioning
confidence: 99%
“…Mitochondrial dysfunction, reduced neurogenesis, microglia activation, and gut microbiota alterations have been associated with an HSD [ 100 , 165 , 166 , 167 ]. Moreover, while HSu exposure produced no effect on inflammation and metabolism [ 100 , 163 , 171 ], HFru was clearly deleterious [ 166 , 168 , 171 ].…”
Section: High-sugar Dietmentioning
confidence: 99%