Irreversible gonadal damage in male survivors of pediatric Hodgkin's disease

Abstract

Gonadal function of long term survivors of pediatric Hodgkin's disease treated with MOPP chemotherapy is severely impaired permanently.

Preservation of Fertility in Pediatric and Adolescent Patients With Cancer

“…Adolescent boys and young men treated for Hodgkin's disease with 6 cycles of chemotherapy, including nitrogen mustard, vincristine, prednisone, and procarbazine, had a greater than 90% risk of infertility, primarily attributable to azoospermia. 29,30 In contrast, azoospermia occurred in only 50% of patients receiving 3 cycles or fewer 29 and in 33% of patients treated with an alternative regimen of adriamycin, bleomycin, vinblastine, and dacarbazine. 1 The effect of chemotherapy on ovarian function and subsequent recovery is often unknown.…”

Função gonadal de sobreviventes de doença de Hodgkin tratados na infância e adolescência com quimioterapia

“…No protocolo C-MOPP/ABV que foi utilizado neste estudo, as doses de ciclofosfamida e procarbazina, que são os quimioterápicos que mais interferem na função gonadal, são reduzidas em cerca de 50% quando comparadas aos outros protocolos utilizados no tratamento da Doença de Hodgkin (10,12,15,16).…”

“…Neste protocolo, apesar da utilização de diversos quimioterápicos, as doses de ciclofosfamida e de procarbazina são reduzidas em 50% em relação a outros protocolos (10,16).…”

Prevention of male infertility in the treatment of tumors. Problems and solutions

“…Некоторые исследователи полагают, что проведе-ние противоопухолевой терапии до наступления по-лового созревания не оказывает существенного вли-яния на репродукцию, подчеркивая бόльшую резистентность гонад к химиотерапии у подростков, по сравнению с взрослыми [33]. Однако имеющиеся наблюдения за пациентами после терапии ЛХ, свиде-тельствуют обратное, показывая, что химиотерапия до наступления полового созревания может приво-дить к полной и необратимой утрате репродуктивных функций [34][35][36][37].…”