Irreversible Electroporation of Hepatic and Pancreatic Malignancies: Radiologic-Pathologic Correlation

Gonzalez-Beicos, Aldo; Venkat, Shree; Songrug, Tanakorn; Poveda, Julio; García-Buitrago, Mónica; Mohan, Pradeep; Narayanan, Govindarajan

doi:10.1053/j.tvir.2015.06.009

Cited by 14 publications

(9 citation statements)

References 23 publications

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“…Biliary tree abnormalities, such as common bile duct dilatation and pancreatic ductal gas, were less common and typically delayed. A separate study by Gonzalez-Beicos et al found no evidence of vascular narrowing or obliteration, 25 though it is noteworthy that this study included only three patients who underwent IRE in the pancreas.…”

Section: Post-ire Follow-up and Imaging Appearancesmentioning

confidence: 74%

Irreversible Electroporation of the Pancreas

Chan

Pua

2019

Semin intervent Radiol

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Irreversible electroporation (IRE) is a relatively recent method of ablation. In contrast to many ablation devices that use thermal methods to induce cell death, IRE employs the use of an electric field to cause irreversible permeability of the cell membrane, thus inducing apoptosis. Since its use in the pancreas was first described in 2012, IRE has become established as part of the armamentarium of ablation devices currently available. The crucial advantage of IRE compared with other devices employing thermal ablation is the safety around vital structures such as vessels and ducts. This is especially important in the pancreas due to the close proximity of multiple major vascular structures, biliary ducts, and adjacent gastrointestinal organs. This article will explore the current evidence regarding the use of IRE in the pancreas.

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Section: Post-ire Follow-up and Imaging Appearancesmentioning

confidence: 74%

Irreversible Electroporation of the Pancreas

Chan

Pua

2019

Semin intervent Radiol

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“…A total of 43 patients (RFA = 22, IRE = 21) were included, and postprocedural pain was comparable in both groups [33,34]. In another recent trial, Niessen et al [35] evaluated the risk factors associated with short-term local recurrence after IRE. Twenty-five patients with 48 malignant liver lesions (HCC = 22; cholangiocarcinoma = 6; metastases = 20) underwent IRE.…”

Section: Irreversible Electroporationmentioning

confidence: 98%

New Approaches in Locoregional Therapies for Hepatocellular Carcinoma

Méméo

Blasi

Cherkaoui

et al. 2016

J Gastrointest Canc

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“…In this sense, frequent findings were abdominal wall edema or ascites, with no clinical impact, or even gastrointestinal hemorrhage, portal vein thrombosis or bowel perforation with clear clinical impact (46). The effect of IRE on vessel wall is still debated, as some authors report a narrowing/ compression (46), but some others do not (47). The tumorous findings are heterogeneous, as immediately after IRE the ablation zone might be bigger than expected and hypodense.…”

Section: Imagingmentioning

confidence: 99%

Palliative therapy in pancreatic cancer—interventional treatment with radiofrequency ablation/irreversible electroporation

Paiella

Pastena

D’Onofrio

et al. 2018

Transl. Gastroenterol. Hepatol

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Pancreatic cancer (PC) is a solid tumor with still a dismal prognosis. Diagnosis is usually late, when the disease is metastatic or locally advanced (LAPC). Only 20% of PC are amenable to surgery at the time of diagnosis and the vast majority of them, despite radically resected will unavoidably recur. The treatment of LAPC is a challenge. Current guidelines suggest to adopt systemic therapies upfront, based on multi-drugs chemotherapy regimens. However, the vast majority of patients will never experience conversion to surgical exploration and radical resection. Thus, there a large subgroup of LAPC patients where the only therapeutic chance is to offer palliative treatments, such as interventional ablative treatments, in order to obtain a cytoreduction of the tumor, trying to delay its growth and spread. Radiofrequency ablation (RFA) and irreversible electroporation (IRE) demonstrated to be safe and effective in obtaining a local control of the disease with some promising oncological results in terms of overall survival (OS). However, they should be adopted as a treatment strategy to adopt in parallel with other systemic therapies, within multidisciplinary choices. They are not free from complications, even serious, thus they should applied only in specialized centers of pancreatology. This review depicts the state of the art of the two techniques.

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Irreversible Electroporation of Hepatic and Pancreatic Malignancies: Radiologic-Pathologic Correlation

Cited by 14 publications

References 23 publications

Irreversible Electroporation of the Pancreas

Irreversible Electroporation of the Pancreas

New Approaches in Locoregional Therapies for Hepatocellular Carcinoma

Palliative therapy in pancreatic cancer—interventional treatment with radiofrequency ablation/irreversible electroporation

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