Irreversible cochlear damage in myasthenia gravis - otoacoustic emission analysis

Hamed, Sherifa A.; Elattar, Amal M.; Hamed, Enas A.

doi:10.1111/j.1600-0404.2005.00541.x

Cited by 16 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with MG, autoantibodies against AChRs were reported to bind with AChRs on OHCs, inducing a progressive loss of AChRs that decreases OHC electromotility [114]. This cascade of events induces apoptosis in all three rows of OHCs, evolving into a clinically evident SNHL in rare cases [115].…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

“…CAS produces physiological suppression of otoacoustic emissions [117] protecting the hair cells from noise of moderate to high intensity [118]. A reduced CAS effect has been reported in patients with MG compared to control subjects, suggesting a possible role of the progressive reduction of beta subunits of nicotinic AChRs associated to the destruction of the basal membrane and OHCs due to prolonged exposure to autoantibodies [114, 116]. …”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

“…A specific test studying, the activity of the OHC, otoacoustic emissions (OAE), may show some abnormalities, as OAE have been found to exhibit greater sensitivity to incipient cochlear damage compared to PTA, particularly for high frequencies [115, 119]. A study on 16 MG patients reported a clinical hearing loss in 30% of the patients, while 100% of the patients exhibited abnormal distortion product otoacoustic emissions (DPOAEs) and transient evoked otoacoustic emissions (TEOAEs) [114]. Therefore, OAE should always be performed in MG patients because they can early detect the MG-related effects on the ACh-innervated auditory system [111].…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

View full text Add to dashboard Cite

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

show abstract

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…The affected patients show hearing loss particularly to high frequency waves (above 30 decibels). A number of human studies have shown progression of MG associated with irreversible cochlear damage causing sudden loss in hearing (Arnold, 1997;Hamed et al, 2006). MG could cause non suppurative otitis media, leading to hearing loss (Brookler et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

The diagnosis and treatment of acquired Myasthenia Gravis in two adult dogs using oral neostigmine bromide

et al. 2016

View full text Add to dashboard Cite

Summary: Two adult dogs aged 3.5 and 9 years were diagnosed with acquired Myasthenia Gravis (MG) based on clinical signs and positive response to oral neostigmine bromide (0.25mg/Kg BW) within 4 hours of oral administration. Both patients were successfully treated using neostigmine (1mg/Kg BW daily) alone or with neostigmine (1mg/Kg BW daily) and prednisolone (1mg/Kg BW, q12h) combination. Serum alkaline phosphatase and albumin/ globulin ratio monitored in one of the above patients starting from one month prior to development of generalized clinical signs until complete recovery, showed significant alterations which can be used in diagnosing MG and in monitoring the response to treatment. BACKGROUND

show abstract

“…However, they are major causes of morbidity and mortality. Other nervous system manifestations were also reported in some patients with MG as memory difficulties and cognitive impairment [15][16][17][18], autonomic dysfunction [19,20], sensorineural hearing loss [21] and psychiatric disorders [22] which are also related to sleep abnormalities with MG [7]. Several central (e.g.…”

Section: Introductionmentioning

confidence: 99%

Sleep Related Conditions with Myasthenia Gravis: Evidence, Causes and Implications

Hamed¹

2016

SJPH

View full text Add to dashboard Cite

Myasthenia gravis (MG) is an autoimmune disease caused mainly by antibodies against skeletal muscle nicotinic acetylcholine receptors (nAChRs) at the postsynaptic membrane resulting in depletion of acetylcholine at the neuromuscular junction (NMJ). Muscle fatigue is the cardinal symptom of MG. Respiratory muscle weakness and breathing problems are manifestations of MG even in mild stages of the disease resulting in significant morbidity and mortality. Also sleep related conditions are among the manifestations of MG which include sleep disordered breathing (SDB) [i.e. central (CSA) and obstructive (OSA) sleep apneas, hypoventilation or hypoxemic syndromes], reduced sleep efficiency and quality, increased number of nocturnal awakenings, excessive daytime sleepiness, reduced rapid eye movement sleep and altered sleep perception and dreaming. On the other hand, sleep abnormalities may result in lack of concentration, cognitive impairments and mood disturbances as depression and anxiety. Central and peripheral mechanisms have been suggested for the association between MG and central nervous system manifestations and sleep abnormalities. Neurologists and sleep medicine professionals should be aware of the associations between OSA/CSA, hypoventilation and other sleep related conditions with MG and consider systematic investigations including polysomnography and ventilatory support. This will reduce morbidity and mortality and improve quality of lives of patients with MG.

show abstract

Irreversible cochlear damage in myasthenia gravis - otoacoustic emission analysis

Abstract: It is clear that disease progression is associated with irreversible cochlear damage. Lack of improvement in patients' emissions despite partial non-audiometric improvement in relation to receptors needs to be considered.

Cited by 16 publications

References 28 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

The diagnosis and treatment of acquired Myasthenia Gravis in two adult dogs using oral neostigmine bromide

Sleep Related Conditions with Myasthenia Gravis: Evidence, Causes and Implications

Contact Info

Product

Resources

About