Irregular Monoterpenes in Essential Oils with Special Emphasis on<i>ortho</i>-Menthane Derivatives

Minteguiaga, Manuel; Catalán, César A.N.; Dellacassa, Eduardo

doi:10.1021/bk-2022-1433.ch009

Cited by 2 publications

(2 citation statements)

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“…Wang et al, 2019;Xie et al, 2019;Dusséaux et al, 2020;Fuentes et al, 2016). However, very few examples exist of the production of irregular monoterpenoids, and many of their biosynthetic pathways remain unknown (Minteguiaga et al, 2023). The most widely studied among irregular monoterpene derivatives is chrysanthemic acid, for its importance as the monoterpene moiety of type I pyrethrins.…”

Section: Discussionmentioning

confidence: 99%

“…This is the case of plants producing lavandulyl pyrophosphate (LPP) and chrysanthemyl pyrophosphate (CPP), irregular branched and cyclic monoterpenoids, respectively (Figure 1A). LPP and its derivatives lavandulol and lavandulyl acetate are produced by various lavender species (Lamiaceae) and by some Apiaceae and are important fragrances, while CPP and the alcohol chrysanthemol are produced by members of the Anthemidae tribe within the Asteraceae family (Minteguiaga et al, 2023). LPP and CPP are the precursors of a variety of bioactive compounds important for pest management.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of tobacco andN. benthamianaas biofactories of irregular monoterpenes for sustainable crop protection

Mateos-Fernández

Vacas²,

Navarro

et al. 2023

Preprint

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Irregular monoterpenes are important precursors of different compounds employed in pest control such as insecticides and insect sex pheromones. Metabolically engineered plants are appealing as biofactories of such compounds, but specially as potential live biodispensers of related bioactive volatiles, which could be continuously emitted to the environment from different plant tissues. Here we assess the use of cultivated tobacco and Nicotiana benthamiana as biofactories for the irregular monoterpenes chrysanthemol and lavandulol. We evaluate the impact of high levels of constitutive metabolite production on the plant physiology and biomass, and their biosynthetic dynamics for different plant tissues and developmental stages. As an example of an active pheromone compound, we super-transformed the best lavandulol-producing tobacco line with an acetyl transferase gene to obtain a tobacco lavandulyl acetate biodispenser emitting up to 0.63 mg of lavandulyl acetate per plant every day. We estimate that with these volatile emission levels, between 200 and 500 plants per hectare would be sufficient to ensure a daily emission of pheromones comparable to commercial lures. This is an important step towards plant-based sustainable solutions for pest control, and it lays the ground for further developing biofactories for other irregular monoterpenoid pheromones, whose biosynthetic genes are yet unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%