Irrational use of proton pump inhibitors in general practise

Ali, Osama; Poole, Robyn; Okon, M; Maunick, Sheevam; Troy, Emma

doi:10.1007/s11845-018-1891-1

Cited by 16 publications

(12 citation statements)

References 10 publications

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“…In this study, the average use rate of PPIs before intervention was 27.05%, which was basically consistent with the literature reports [12]; irrational use of drugs was 47.60%, higher than reported in the literature (34.00%) [13]. Among the patients with irrational use of drugs, 65.60% of the drugs were not indicated, and the preventive drug was not suitable for 22.02%, indicating that the clinical drug indications were not well mastered.…”

Section: Discussionsupporting

confidence: 92%

Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

Qing

Wei

et al. 2019

Preprint

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Background. To investigate the intervention effect of clinical pharmacists on irrational use of proton pump inhibitors (PPIs) in clinicians. Methods. A cross-sectional study was used to through the hospital information management system survey, before intervention (July 15th, 2016, Aug 15th, 2016 and Sep 15th 2016) and dry prognosis (July 15th, 2017, Aug 15th, 2017 and Sep 15th, 2017) all the use of PPIs inpatients related information. According to the guidelines of "drug instructions" and "experts on stress ulcer prevention and treatment experts", the standard of drug use was formulated, and the use of PPIs before and after intervention was evaluated and analyzed in accordance with the standard, and the results of intervention were evaluated. Results. The total number of hospitalized patients surveyed before the intervention was 1,693, the average utilization rate of proton pump inhibitors was 27.05% and the coincidence rate was 52.40%. The total number of hospitalized patients investigated after the intervention was 2,095, the average utilization rate of proton pump inhibitors was 8.54%, and the coincidence rate was 68.16%. Before and after the intervention, there was no difference in gender ratio and age distribution, the decrease of the utilization rate and the improvements of the qualified rate after intervention were statistically significant.Conclusion. According to the standards of PPIs, clinical pharmacists strictly implement the special prescription review system and other intervention measures, which can significantly improve the level of PPIs rational clinical medication.

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Section: Discussionsupporting

confidence: 92%

Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

Qing

Wei

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…The research finding was in a backdrop of the commonest PPI prescription indication that was associated with the reduction in the gastric ulceration risks that comes about as a result of the NSAID use. 13 Despite the increasing concerns about proton pump inhibitors, their use has been frequently adopted with available literature. Most of the literature has evaluated the correct versus the wrong PPI use on a global scale.…”

Section: Research Articlementioning

confidence: 99%

Irrational Prescribing Habit of Omeprazole

Alshammari¹

2020

Preprint

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The primary aim of the study is to examine the frequency of omeprazole prescription from all the prescriptions received by a pharmacist in a single day. Besides, the author examines the cost of dispensed omeprazole. This research is inspired by the fact that medication errors were the leading cause of severe physical injury and death to patients. Additionally, such preventable errors are also associated with intense financial, emotional as well as psychological stress to both healthcare providers and the healthcare organization in general. The study adopted a cross sectional study through collecting as well as screening of all the prescription orders undertaken in one day from 7:30 am to 1:45 pm. The research found that a prescription error leads to wastage of the resources with estimated annual cost of 336,415.56 for omeprazole as well as 431037.984 USD for ranitidine while at the same time necessitates the rational prescription habit to suppress the detrimental effects of omeprazole and ranitidine.

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“…Overutilization of PPI in the medical department was inappropriately linked to stress ulcer prophylaxis as a main indication [10]. Discharge on acid suppressive medication indicated for stress ulcer prophylaxis is one of the manifestations of irrational use documented in literature [11]. Another example of malpractice is the prescribing of PPIs for elderly patients without documented indication [12].…”

Section: Introductionmentioning

confidence: 99%

Review of drug indications for proton pump inhibitors among hospitalized patients in King Fahd Hospital, Alkobar, Saudi Arabia

Abubaker¹,

Royes²,

Abdulsalam³

et al. 2020

World J. Adv. Res. Rev.

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Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide. Irrational use of PPIs is a common practice among hospitalized patients. The major objective of this study was to determine the appropriateness of indications of PPIs among hospitalized patients in King Fahd Hospital, Al Khobar, Saudi Arabia. A cross-sectional study was conducted at King Fahd Hospital, during December 2018 to March 2019. All adult patients admitted to the Medical and Surgical Departments were eligible. Data was collected from each patient's medical record using a structured -data collection form. Assessment of the appropriateness of PPIs indications was performed based on standardized criteria. Descriptive statistics were used to describe all variables. Regression models were performed to identify the determinants of inappropriateness of PPIs indication. A p-value less than 0.05 was considered as statistically significant. Overall, a total of 181 patients was included, of them 96 (53%) were males. Patients aged > 65 years were 47 (26%). Out of all patients PPIs was prescribed as prophylactic therapy for 163 (90.1%) and for 18 (9.9%) as treatment. For 128 (70.7%) patients PPIs was inappropriately indicated. Multiple logistic regression analysis showed that, age more than 65 years 3), (P <0.001)] was significantly associated with appropriate indication of PPIs. PPIs indications was irrational as it was inappropriately prescribed for a considerable number of patients. Urgent interventions are needed to improve the quality of prescribing of this important class of drugs.

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Irrational use of proton pump inhibitors in general practise

Abstract: Irrational prescribing of PPIs continues both in hospital and in general practise. It is imperative that the side-effects of these medicines are weighed against the benefit and cost effectiveness, especially in the elderly population where polypharmacy remains a substantial concern.

Cited by 16 publications

References 10 publications

Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

Irrational Prescribing Habit of Omeprazole

Review of drug indications for proton pump inhibitors among hospitalized patients in King Fahd Hospital, Alkobar, Saudi Arabia

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