Irradiation partielle et accélérée du sein: un concept pour une individualisation thérapeutique dans le cancer du sein

Belkacémi, Yazid; Comet, B.; Hannoun-Lévi, J.-M.; Villette, S.; Marsiglia, H.; Leblanc-Onfroy, M.; Delalande, B; Azria, D.; Dubois, J B

doi:10.1016/j.canrad.2007.09.145

Cited by 9 publications

(2 citation statements)

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“…In observational studies, treatment options are frequently influenced by an individual's characteristics (14,15). Furthermore the baseline characteristics of individuals who receive treatment are frequently systematically different from those of untreated individuals (16).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study

et al. 2019

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The present study aimed to evaluate the significance of post-mastectomy radiotherapy (PMRT) in patients with early stage (T1-2) breast cancer. The Surveillance, Epidemiology, and End Results database was searched, and data on female patients with early stage (T1-2) breast cancer with 1-3 positive axillary lymph nodes (LNs) were extracted. Patients were subdivided into two groups: Those who had received PMRT and those who had not (no PMRT). Data from the two groups were analyzed in order to identify associations between PMRT status, breast cancer-specific survival (BCSS) probability and overall survival (OS) probability using multivariate Cox proportional hazards regression and propensity score matching models. A total of 7,316 patients were included in the analysis. Prior to propensity score matching, outcome probabilities were increased in the PMRT group, compared with the no PMRT group (BCSS probabilities: 92.0 vs. 90.1%, respectively, P= 0.015; OS probabilities: 89.8 vs. 86.0%, respectively, P<0.001). In multivariate analyses, tumor location was not identified as being a risk factor for BCSS (hazard ratio, 0.917; 95% confidence interval, 0.772-1.090; P= 0.326). Following propensity score matching, differences between the two treatment groups (PMRT and no PMRT) in terms of their BCSS scores remained significant (93.7 vs. 90.1%, respectively; P=0.007). Compared with the no PMRT group, the OS probabilities of the PMRT group were increased (89.4 vs. 86.0%; P=0.025). In conclusion, the present results indicated that PMRT may benefit the prognosis of patients with breast cancer with early stage disease (T1-2), and those with one to three positive axillary LNs.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study

et al. 2019

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“…Issue de l'ensemble de cette réflexion, l'irradiation partielle et accélérée du sein a connu ses premiers développements dans les années 1980 [15,16]. Suivant la même désescalade que la chirurgie, elle suppose que, pour certaines patientes, seule l'irradiation du lit d'exérèse tumoral est suffisante pour obtenir le même taux de contrôle local que celui obtenu avec l'irradiation de la totalité du sein [17,18].…”

Section: Introductionunclassified

État de l’art et perspectives de l’irradiation partielle et accélérée du sein en 2014

Chand-Fouché

Hannoun‐Lévi

2014

Cancer/Radiothérapie

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Cancers du sein T1a,b N0 M0 (RPC 2013)

Cottu

Lacroix-Triki²,

Jacot³

et al. 2013

Oncologie

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Irradiation partielle et accélérée du sein: un concept pour une individualisation thérapeutique dans le cancer du sein

Cited by 9 publications

References 55 publications

Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study

Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study

État de l’art et perspectives de l’irradiation partielle et accélérée du sein en 2014

Cancers du sein T1a,b N0 M0 (RPC 2013)

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