Irradiation of the Thyroid as a Cause of Parathyroid Adenoma

Triggs, Stella M.; Williams, E. D.

doi:10.1016/s0140-6736(77)92017-7

Cited by 43 publications

(13 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hamilton et al [16] found no dose-relationship between the radioactive exposure and the incidence of parathyroid tumours. The results observed in rats exposed to radioactive iodine may not be relevant for humans due to their young age at exposure and the high doses given to rats compared to humans [14,15]. Anatomical differences in the location of the parathyroid glands between rats and humans must also be considered.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk of parathyroid adenomas in patients with thyrotoxicosis exposed to radioactive iodine

Rasmuson¹,

Tavelin²

2006

Acta Oncologica

View full text Add to dashboard Cite

External ionizing radiation is a risk factor for primary hyperparathyroidism. Whether exposure to radioactive iodine contributes to the risk of primary hyperparathyroidism is unknown. Patients with thyrotoxicosis are often treated with radioactive iodine and its accumulation in the thyroid gland exposes the adjacent parathyroid glands to radioactivity. Six thousand and eighty two patients with thyrotoxicosis (ICD-9 = 242) were identified from medical records. In a randomly selected subcohort we assessed the frequency of treatment with radioactive iodine to be 86%. The number of patient-years at risk was 77,118. Patients with parathyroid adenomas (ICD-9 = 195.1) were recruited from the Swedish Cancer Registry. Eleven patients with parathyroid adenomas following the diagnosis of thyrotoxicosis were identified. The standard incidence ratio (SIR) compared to the reference population of approximately 900,000 was 1.14 (95% CI 0.57-2.03). The median age at exposure was 59 years and the latency period between diagnosis of thyrotoxicosis and parathyroid adenoma was 7.4 years (range <1-19 years). This study does not indicate that patients with thyrotoxicosis treated with radioactive iodine in adult age have increased risk of developing parathyroid adenoma.

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, rats exposed to radioactive iodine had a significantly increased risk of developing parathyroid adenomas [14,15]. A recent report on human exposure of radioactive iodine at young age in a region surrounding a nuclear site showed no increased incidence of hyperparathyroidism [16].…”

mentioning

confidence: 99%

Risk of parathyroid adenomas in patients with thyrotoxicosis exposed to radioactive iodine

Rasmuson¹,

Tavelin²

2006

Acta Oncologica

View full text Add to dashboard Cite

show abstract

“…Whereas one patient's lethal hepatic necrosis likely resulted from antithyroid medications, the second patient death 10 d after treatment seems directly related to RAI therapy. In contrast, the mortality rate after thyroidectomy is less than 0.1% and in some large series is 0% in patients with Graves' disease (16,25,26).…”

mentioning

confidence: 85%

“…Indeed, Esselstyn et al (21) found an incidence of hyperparathyroidism after RAI that was "several times normal." Similarly, Triggs and Williams (16) reported that 10 of 159 patients developed hyperparathyroidism after RAI therapy for Graves' disease as children or adolescents, a rate that is higher than expected from the general population. In addition, Ito and colleagues (18,20) found that patients treated with RAI were more likely to develop hyperparathyroidism than those treated with antithyroid drugs.…”

mentioning

confidence: 96%