Irradiation Induced Fluorescence Enhancement in PEGylated Cyanine-Based NIR Nano- and Mesoscale GUMBOS

Lu, Cewu; Das, Susmita; Magut, Paul K. S.; Li, Min; El‐Zahab, Bilal; Warner, Isiah M.

doi:10.1021/la302428a

Cited by 35 publications

(34 citation statements)

References 42 publications

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“…15 By functionalization with magnetic NPs and polymers, the stokes shift of IR-820 could be tuned. 16 New octupolar merocyanine chromophores developed by Poronik et al could also be easily tuned into the NIR region.…”

Section: Cyanine Dyesmentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

211

149

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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Section: Cyanine Dyesmentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

211

149

View full text Add to dashboard Cite

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“…GUMBOS showed a large Stokes shift of 122 nm, as measured by UV spectroscopy, which is a positive feature for in vivo imaging where long wavelength dyes offer better light penetration. 36 …”

Section: Cancer Imaging Using Heptamethine Nirf Nanocomplexesmentioning

confidence: 99%

NIRFHeptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors

Thomas

Jeong

2017

Chonnam Med J

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Heptamethine cyanine dyes are categorized as a class of near infrared fluorescent (NIRF) dyes which have been discovered to have tumor targeting and accumulation capability. This unique feature of NIRF dye makes it a promising candidate for imaging, targeted therapy and also as a drug delivery vehicle for various types of cancers. The favored uptake of dyes only in cancer cells is facilitated by several factors which include organic anion-transporting polypeptides, high mitochondrial membrane potential and tumor hypoxia in cancer cells. Currently nanotechnology has opened possibilities for multimodal or multifunctional strategies for cancer treatment. Including heptamethine cyanine dyes in nanoparticle based delivery systems have generally improved its theranostic ability by several fold owing to the multiple functionalities and structural features of heptamethine dyes. For this reason, nanocomplexes with NIRF heptamethine cyanine dye probe are preferred over non-targeting dyes such as indo cyanine green (ICG). This review sums up current trends and progress in NIRF heptamethine cyanine dye, including dye properties, multifunctional imaging and therapeutic applications in cancer.

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“…Such an effect was also observed in previous studies and was attributed to irradiation induced J-aggregation. 28 We note that photostability of fluorescent nanomaterials is an extremely important factor for determining sensor applicability in adverse conditions. Thus, the observed enhanced photostability in solutions and extremely high (100 %) photostability of the nanodroplets of these materials are considered an additional advantage of the materials.…”

Section: Optical Properties Of Ph Dependent Ttp Nanomaterialsmentioning

confidence: 99%

Ionic liquid-based fluorescein colorimetric pH nanosensors

et al. 2013

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A novel pH sensitive, colorimetric ionic liquid nanosensor based on phosphonium salts of fluorescein is reported. Herein, fluorescein salts of various stoichiometries were synthesized by use of a trihexyltetradecylphosphonium cation [TTP]+ in combination with dianionic [FL]2− and monoanionic [FL]− fluorescein. Nanomaterials derived from these two compounds yielded contrasting colorimetric responses in neutral and acidic environments. Variations in fluorescence spectra as a function of pH were also observed. Examination of TEM and DLS data revealed significant expansion in the diameter of [TTP]2[FL] nanodroplets in acidic environments of variable pHs. A similar trend was also observed for [TTP][FL] nanoparticles. The pH dependent colorimetric and other optical properties of these nanomaterials are attributed to alterations in molecular orientations and stacking as suggested by measuring the absorption, fluorescence, and zeta potential. Since the pH is an important indicator for many diseases, including cancer, these nanosensors are considered to be potential candidates for biomedical applications.

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Irradiation Induced Fluorescence Enhancement in PEGylated Cyanine-Based NIR Nano- and Mesoscale GUMBOS

Cited by 35 publications

References 42 publications

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

NIRFHeptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors

Ionic liquid-based fluorescein colorimetric pH nanosensors

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