Irradiation Behavior of Analgesic and Nonsteroidal Anti-Inflammatory Drug-Loaded UHMWPE for Joint Replacement
Sashank Lekkala,
Nicoletta Inverardi,
Scott C. Grindy
et al.
Abstract:Local delivery of pain medication can be a beneficial strategy to address pain management after joint replacement, as it can decrease systemic opioid usage, leading to less side and long-term effects. In this study, we used ultrahigh molecular weight polyethylene (UHMWPE), commonly employed as a bearing material for joint implants, to deliver a wide set of analgesics and the nonsteroidal anti-inflammatory drug tolfenamic acid. We blended the drugs with UHMWPE and processed the blend by compression molding and … Show more
Diffusion of therapeutics into solid form UHMWPE enabled a therapeutic material with superior mechanical and tribological properties to phase-separated drug-loaded UHMWPEs, which are prepared by mechanical blending.
Diffusion of therapeutics into solid form UHMWPE enabled a therapeutic material with superior mechanical and tribological properties to phase-separated drug-loaded UHMWPEs, which are prepared by mechanical blending.
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