Irradiated laboratory animal diets

Anderson, Diana; Clapp, M. J. L.; Hodge, M.C.E.; Weight, T.M.

doi:10.1016/0027-5107(81)90106-8

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…Similar results were observed in animal studies 41 - 47 . An increased number of embryonic deaths, due to lethal mutations and gross chromosomal aberrations, was noticed among litters of mice that consumed irradiated food 41 - 42 . Higher number of polyploidy cells in bone marrow and significant amount of aneuploidy cells in testis accompanied by increased mutagenic index was noticed in mice, rats and hamsters that were fed with irradiated wheat compared to the animals that were on standard diet 44 - 47 .…”

Section: Consumption Of Irradiated Food: What Have We Learnt From Animentioning

confidence: 99%

Risks of Using Sterilization by Gamma Radiation: The Other Side of the Coin

Harrell¹,

Djonov

Fellabaum³

et al. 2018

Int. J. Med. Sci.

124

102

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The standard sterilization method for most medical devices over the past 40 years involves gamma irradiation. During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors. Accordingly, gamma radiation significantly alters biomechanical properties of bone, tendon, tracheal, skin, amnion tissue grafts and micronized amniotic membrane injectable products. Similarly, when polymer medical devices are sterilized by gamma radiation, their physico-chemical characteristics undergo modification significantly affecting their clinical use.Several animal studies demonstrated that consummation of irradiated food provoked genome instability raising serious concerns regarding oncogenic potential of irradiated consumables. These findings strongly suggest that new, long-term, prospective clinical studies should be conducted in near future to investigate whether irradiated food is safe for human consumption. In this review, we summarized current knowledge regarding molecular mechanisms responsible for deleterious effects of gamma radiation with focusing on its significance for food safety and biomechanical characteristics of medical devices, and tissue allografts, especially injectable biologics.

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