Irradiated Cell-Derived Exosomes Transmit Essential Molecules Inducing Radiation Therapy Resistance

Li, Yiling; Huang, Linyang; Chen, Yanchi; Shi, Yixin; Ze, Yiting; Yao, Yang

doi:10.1016/j.ijrobp.2022.01.036

Cited by 5 publications

(2 citation statements)

References 118 publications

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“…In this work, we demonstrated that exosomes mediated inflammatory responses of fine atmospheric particulate matter in macrophages as essential intercellular messengers (Scheme ). Of note, we developed a quantitative method (SDS-PAGE) of PM 2.5 in biological samples and revealed that exosomes served as a mediator for PM 2.5 transfer between cells, thus emphasizing a new capacity of exosomes distinct from all other known abilities of exosomes transporting biological molecules. − Most importantly, we elucidated a novel mechanism for the inflammatory responses of macrophages to PM 2.5 in which particles, by activating P2X7R, stimulated the substantial secretion of exosomes, thus resulting in increased inflammatory responses and cytokines release (TNF-a and IL-1β) of recipient macrophage through activation of the TLR-4-NF-κB signaling pathway. Overall, these results support the emerging perspective that the toxic effects of particles can be determined by the released extracellular vesicles and provide compelling evidence that exosomes can induce the inflammatory responses of macrophages.…”

Section: Resultsmentioning

confidence: 94%

The Exosome-Mediated Cascade Reactions for the Transfer and Inflammatory Responses of Fine Atmospheric Particulate Matter in Macrophages

Cui

Lai

Zhao

et al. 2023

Environ. Sci. Technol.

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Exposure to atmospheric particulate matter (PM) is a frequent occurrence to humans, and their adverse outcomes have become a global concern. Although PM-induced inflammation is a common phenomenon, a clear picture of the mechanisms underlying exosome-mediated inflammation of PM has not yet emerged. Here, we show that exosomes can mediate the cascade reactions for the transfer of PM and inflammatory responses of macrophages. Specifically, two fine PM2.5, namely F1 (<0.49 μm) and F2 (0.95–1.5 μm), stimulated a substantial release of exosomes from macrophages (THP-1 cells) with the order of F1 > F2, via regulation of the P2X7 receptor (P2X7R). Inhibiting P2X7R with a specific inhibitor largely prevented the secretion of exosomes. In particular, we found that exosomes served as a mediator for the transfer of PM2.5 to the recipient macrophages and activated NF-κB signaling through toll-like receptor 4 (TLR-4), thereby stimulating inflammatory cytokine release and altering the inflammatory phenotype of recipients. Importantly, the exosomes derived from PM2.5-treated macrophages induced the inflammatory responses of lung in mice. Our results highlight that exosomes undergo a secretion–particle transfer–adverse outcome chain in macrophages treated with PM2.5. Given the ubiquitous atmospheric particulate matter, these new findings underscore an urgent need for assessing the secretion of exosomes and their impact on human health via exosome-centric physiological pathways.

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Section: Resultsmentioning

confidence: 94%

The Exosome-Mediated Cascade Reactions for the Transfer and Inflammatory Responses of Fine Atmospheric Particulate Matter in Macrophages

Cui

Lai

Zhao

et al. 2023

Environ. Sci. Technol.

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“…1d ), mainly through modulating DDR, cell death signals, and the EMT. 71 In HNSCC radiation-resistance cases, the functions of tumor-promoting exosomes are strengthened after radiation. 72 …”

Section: Exosomes In the Progression Of Oral Diseasesmentioning

confidence: 99%

Emerging roles of exosomes in oral diseases progression

Wang,

Jing,

Zhou

et al. 2024

Int J Oral Sci

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Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient’s digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients’ prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine. Exosomes, which are characterized as nanometer-sized extracellular vesicles, are secreted by virtually all types of cells. As the research continues, the complex roles of these intracellular-derived extracellular vesicles in biological processes have gradually unfolded. Exosomes have attracted attention as valuable diagnostic and therapeutic tools for their ability to transfer abundant biological cargos and their intricate involvement in multiple cellular functions. In this review, we provide an overview of the recent applications of exosomes within the field of oral diseases, focusing on inflammation-related bone diseases and oral squamous cell carcinomas. We characterize the exosome alterations and demonstrate their potential applications as biomarkers for early diagnosis, highlighting their roles as indicators in multiple oral diseases. We also summarize the promising applications of exosomes in targeted therapy and proposed future directions for the use of exosomes in clinical treatment.

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Cancer stem cells (CSCs): key player of radiotherapy resistance and its clinical significance

et al. 2023

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Irradiated Cell-Derived Exosomes Transmit Essential Molecules Inducing Radiation Therapy Resistance

Cited by 5 publications

References 118 publications

The Exosome-Mediated Cascade Reactions for the Transfer and Inflammatory Responses of Fine Atmospheric Particulate Matter in Macrophages

The Exosome-Mediated Cascade Reactions for the Transfer and Inflammatory Responses of Fine Atmospheric Particulate Matter in Macrophages

Emerging roles of exosomes in oral diseases progression

Cancer stem cells (CSCs): key player of radiotherapy resistance and its clinical significance

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