Iron Supplemented Formula Milk Related to Reduction in Psychomotor Decline in Infants From Inner City Areas: Randomised Study

Williams, J. David; Wolff, A.; Daly, Anne; MacDonald, Anita; Aukett, Anne; Booth, I W

doi:10.1097/00004583-199910000-00030

Cited by 39 publications

(68 citation statements)

References 5 publications

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“…Infants who received iron between 1 and 6 months had better motor scores at 12 months, compared to those receiving placebo (Friel et al, 2003). Two preventive trials with healthy term infants did not show motor effects (Morley, Abbott, Fairweather-Tait, MacFayden, & Sterman, 1999;Williams et al, 1999).…”

Section: Introductionmentioning

confidence: 90%

Effects of iron deficiency in infancy on patterns of motor development over time

Shafir

Angulo-Barroso

Calatroni

et al. 2006

Human Movement Science

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This longitudinal study of the effects of iron deficiency in infancy assessed motor development over time in 185 healthy Costa Rican children who varied in iron status at 12-23 months. Longitudinal analyses (hierarchical linear modeling) used the Bayley Psychomotor Index before and both 1 week and 3 months after iron treatment in infancy and the Bruninks-Oseretsky Test of Motor Proficiency -long form at 5 years and short form at 11-14 years. Children with chronic severe iron deficiency in infancy had lower motor scores at the beginning of the study and a lower but parallel trajectory for motor scores through early adolescence. Thus, there was no evidence of catch-up in motor development, despite iron therapy in infancy that corrected iron deficiency anemia in all cases.

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Section: Introductionmentioning

confidence: 90%

Effects of iron deficiency in infancy on patterns of motor development over time

Shafir

Angulo-Barroso

Calatroni

et al. 2006

Human Movement Science

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“…Randomized controlled trials of iron supplementation consistently show improvement in motor (Moffatt et al, 1994), social-emotional (Williams et al, 1999), and language outcomes (Stoltzfus et al 2001). …”

Section: Cognitive Developmentmentioning

confidence: 99%

Iron Deficiency Anemia: A Public Health Problem of Global Proportions

Charles¹

2012

Public Health - Methodology, Environmental and Systems Issues

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“…The applicant identified seven human intervention studies, two observational studies and one meta-analysis as being pertinent to the health claim. The human intervention studies investigated the effect of iron supplementation on mental and/or psychomotor development in iron deficient infants and young children (Aukett et al, 1986;Walter et al, 1989;Williams et al, 1999;Idjradinata and Pollitt, 1993;Moffatt et al, 1994;Lozoff et al, 1996;Morley et al, 1999). The observational studies evaluated the association between iron supplementation and the development of the central nervous system in infants and young children (Roncagliolo et al, 1998;Algarin et al, 2003).…”

Section: Scientific Substantiation Of the Claimed Effectmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to iron and contribution to normal cognitive development pursuant to Article 14 of Regulation (EC) No 1924/2006

Products¹

2013

EFS2

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Following an application from IDACE, submitted pursuant to Article 14 of Regulation (EC) No 1924No /2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to iron and contribution to normal cognitive development. The food constituent, iron, which is the subject of the health claim, is sufficiently characterised. Contribution to normal cognitive development is a beneficial physiological effect for infants and young children. A claim on iron and cognitive development in children (up to 18 years) has already been assessed with a favourable outcome. The Panel notes that the role of iron in normal cognitive development also applies to infants and young children (from birth to three years). The Panel concludes that a cause and effect relationship has been established between dietary intake of iron and contribution to normal cognitive development. The following wording reflects the scientific evidence: "Iron contributes to normal cognitive development". The target population is infants and children up to three years. The scope of the application was proposed to fall under a health claim referring to children's development and health. © EuropeanThe food constituent that is the subject of the health claim is iron, which is a well recognised nutrient and is measurable in foods by established methods. The Panel considers that iron is sufficiently characterised.The claimed effect proposed by the applicant is "important for the cognitive development of infants and young children". The target population proposed by the applicant is "infants and young children from birth to three years of age". The Panel considers that contribution to normal cognitive development is a beneficial physiological effect for infants and young children.The evidence provided by consensus opinions/reports from authoritative bodies and reviews shows that there is consensus on the role of iron in cognitive development and function. Insufficient iron intake results in iron deficiency signs and symptoms, including anaemia, impaired psychomotor development and impaired cognitive performance. The cognitive deficiency symptoms observed in subjects with iron-deficiency anaemia include deficits in attention, perceptual motor speed, memory and verbal fluency.A claim on iron and cognitive development in children (up to 18 years) has already been assessed by the Panel with a favourable outcome. The Panel notes that the role of iron in normal cognitive development also applies to infants and young children (from birth to three years).The Panel concludes that a cause and effect relationship has been established between dietary intake of iron and contribution to normal cognitive development.The following wording reflects the scientific evidence: "Iron contributes to normal cognitive development".The Panel considers that, in order to bear the claim, follow-on formulae should comply with the criteria of composition...

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Iron Supplemented Formula Milk Related to Reduction in Psychomotor Decline in Infants From Inner City Areas: Randomised Study

Cited by 39 publications

References 5 publications

Effects of iron deficiency in infancy on patterns of motor development over time

Effects of iron deficiency in infancy on patterns of motor development over time

Iron Deficiency Anemia: A Public Health Problem of Global Proportions

Scientific Opinion on the substantiation of a health claim related to iron and contribution to normal cognitive development pursuant to Article 14 of Regulation (EC) No 1924/2006

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