Iron supplementation aggravates joint inflammation in mice with acute gouty arthritis

Shen, Jiayan; Xie, Zhaohu; Zhao, Ting; Li, Zhenming; Yang, Qi; Xi, Yujiang; Xiao, Niqing; Wang, Lin; Qin, Dongdong; Peng, Jiangyun; Li, Zhaofu

doi:10.1111/1756-185x.14370

Cited by 1 publication

(1 citation statement)

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“…[ 93 ] Elevated serum uric acid, which is involved in iron metabolism, has been increasingly recognized as a risk factor for gout. [ 94 ] Iron supplementation exacerbates joint inflammation in mice with acute GA. [ 95 ] Targeting iron metabolism to treat GA is also a promising approach. MSU crystals and other particulate matter can induce ferroptosis in various cells, but ferroptosis inhibitors cannot directly prevent MSU crystal-induced necrosis in mouse macrophages.…”

Section: Iron Metabolism and Arthritismentioning

confidence: 99%

Iron metabolism and arthritis: Exploring connections and therapeutic avenues

Zhuo,

Xiao,

Tang

et al. 2024

Chinese Medical Journal

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Iron is indispensable for the viablility of nearly all living organisms, and it is imperative for cells, tissues, and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival. Disruption of iron homeostasis can lead to the development of various diseases. There is a robust connection between iron metabolism and infection, immunity, inflammation, and aging, suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis. Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy. Targeting iron metabolism offers a promising approach for individualized treatment of arthritis. Therefore, this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis. Furthermore, this review aimed to identify potential therapeutic targets and active substances related to iron metabolism, which could provide promising research directions in this field.

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Section: Iron Metabolism and Arthritismentioning

confidence: 99%