Iron stores in pregnant women with sickle cell disease: a protocol for a systematic review and meta-analysis

Aroke, Desmond; Kadia, Benjamin Momo; Njim, Tsi

doi:10.1136/bmjopen-2018-026497

Cited by 2 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature search was done for a period of 1 month (September 15th to October 15th 2019. We used the search strategy and search terms published in the protocol for this study, [19] available on (Additional file 1: Appendix 1). Additionally, we searched the reference lists of eligible studies for article titles with potentially similar objectives.…”

Section: Methodsmentioning

confidence: 99%

“…We aimed to assess the prevalence, associated factors and maternal/foetal outcomes of iron deficiency anaemia among PWSCD. We included all observational studies and clinical trials which provided answers to at least one of the 3 objectives on the iron status in PWSCD as we previously reported [19]. Case reports, commentaries, reviews, editorials, letters, and protocols were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…The protocol for this review was registered with PROSPERO (registration number CRD42018109803) and published in a peer reviewed journal [ 19 ]. The review is reported following the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) guidelines [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Iron stores in pregnant women with sickle cell disease: a systematic review

Aroke

Kadia

Njim

2020

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

Background Gradual improvements in the management of sickle cell disease (SCD), have led to an increase in the number of women with SCD who reach the age of procreation. However, evidence on the iron status of pregnant women with sickle cell disease (PWSCD) remains inconclusive. We conducted the first systematic review on the prevalence, determinants and maternal/foetal outcomes of iron deficiency anaemia among PWSCD. Methods We searched MEDLINE, EMBASE, Global Health, Africa Index Medicus, the Cochrane library databases and reference lists of retrieved publications for studies describing the iron status of PWSCD. The literature search was done over a period of 1 month, with no language or date restrictions applied. Data were extracted on a Microsoft excel sheet. Two authors assessed all included studies for methodological quality and risk of bias. Results A total of 710 reports were identified for title and article screening. Five retained studies were conducted before or during the 90s and included 67 participants. After quality assessment, the observational studies were designated to have a “fair” quality assessment while the randomised control trial had an “unclear” quality assessment. The prevalence of iron deficiency anaemia among PWSCD varied by study design and diagnostic method. The overall prevalence ranged from 6.67–83.33%. None of the studies provided evidence on factors associated with iron deficiency anaemia and the randomized trial reported no difference in outcomes between PWSCD who had iron supplementation and those who did not. Conclusion Evidence on factors associated with iron deficiency anaemia among PWSCD and maternal/foetal outcomes in PWSCD who have iron deficiency anaemia is poor. The studies included in this review suggests that iron deficiency anaemia may be highly prevalent in PWSCD but due to the very small sample sizes and varied study designs, this evidence is inconclusive. The review shows that there is a need for more studies with robust designs and adequate sample sizes to assess the disease burden of iron deficiency anaemia in PWSCD.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Iron stores in pregnant women with sickle cell disease: a systematic review

Aroke

Kadia

Njim

2020

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

show abstract

“…Thus, a proper assessment of chronic disease complications in a multidisciplinary setting (ie, screening pulmonary hypertension, iron overload, hypertension and/or proteinuria, for nephropathy and/or hepatic dysfunction, proliferative retinopathy) should be made and the presence of alloantibodies should be carried out ideally prior to conception. 92 Due to the recurrent blood transfusions, SCD patients are at higher risk of alloimmunization. 93 Almost half of the patients will have alloantibodies which will increase the risk of hemolytic disease in the fetus.…”

Section: Sickle Cell Diseasementioning

confidence: 99%

“…In SCD, prediction of the course of pregnancy is often very difficult to establish due to the variability in the severity of SCD phenotype. Thus, a proper assessment of chronic disease complications in a multidisciplinary setting (ie, screening pulmonary hypertension, iron overload, hypertension and/or proteinuria, for nephropathy and/or hepatic dysfunction, proliferative retinopathy) should be made and the presence of alloantibodies should be carried out ideally prior to conception 92 . Due to the recurrent blood transfusions, SCD patients are at higher risk of alloimmunization 93 .…”

Section: Sickle Cell Diseasementioning

confidence: 99%

Recommendations for Pregnancy in Rare Inherited Anemias

et al. 2020

View full text Add to dashboard Cite

Rare inherited anemias are a subset of anemias caused by a genetic defect along one of the several stages of erythropoiesis or in different cellular components that affect red blood cell integrity, and thus its lifespan. Due to their low prevalence, several complications on growth and development, and multi-organ system damage are not yet well defined. Moreover, during the last decade there has been a lack of proper understanding of the impact of rare anemias on maternal and fetal outcomes. In addition, there are no clear-cut guidelines outlining the pathophysiological trends and management options unique to this special population. Here, we present on behalf of the European Hematology Association, evidence- and consensus-based guidelines, established by an international group of experts in different fields, including hematologists, gynecologists, general practitioners, medical geneticists, and experts in rare inherited anemias from various European countries for standardized and appropriate choice of therapeutic interventions for the management of pregnancy in rare inherited anemias, including Diamond-Blackfan Anemia, Congenital Dyserythropoietic Anemias, Thalassemia, Sickle Cell Disease, Enzyme deficiency and Red cell membrane disorders.

show abstract

Iron stores in pregnant women with sickle cell disease: a protocol for a systematic review and meta-analysis

Cited by 2 publications

References 16 publications

Iron stores in pregnant women with sickle cell disease: a systematic review

Iron stores in pregnant women with sickle cell disease: a systematic review

Recommendations for Pregnancy in Rare Inherited Anemias

Contact Info

Product

Resources

About