Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction ☆

Ekblom, Kim; Marklund, Stefan L.; Jansson, Jan‐Håkan; Hallmans, Göran; Weinehall, Lars; Hultdin, Johan

doi:10.1016/j.ijcard.2010.04.001

Cited by 26 publications

(21 citation statements)

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“…In a prospective nested case-referent study, Ekblom et al (2011) [15] investigated the connection between iron status (measured as plasma iron, TIBC, TS, and ferritin) and the risk of suffering a first MI. The authors found an inverse risk association for MI in the highest quartiles of iron (OR = 0.68; 95% CI: 0.48–0.96) and TS (OR = 0.62; 95% CI: 0.42–0.89) in men.…”

Section: Studies Finding An Association Between Iron and Cvdmentioning

confidence: 99%

Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial

et al. 2013

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Iron is the second most abundant metal in the Earth’s crust. Despite being present in trace amounts, it is an essential trace element for the human body, although it can also be toxic due to oxidative stress generation by the Fenton reaction, causing organic biomolecule oxidation. This process is the basis of numerous pathologies, including cardiovascular diseases (CVD). The relationship between iron and cardiovascular disease was proposed in 1981 by Jerome Sullivan. Since then, numerous epidemiological studies have been conducted to test this hypothesis. The aim of this review is to present the main findings of the chief epidemiological studies published during the last 32 years, since Sullivan formulated his iron hypothesis, suggesting that this element might act as a risk factor for cardiovascular disease. We have analyzed 55 studies, of which 27 supported the iron hypothesis, 20 found no evidence to support it and eight were contrary to the iron hypothesis. Our results suggest that there is not a high level of evidence which supports the hypothesis that the iron may be associated with CVD. Despite the large number of studies published to date, the role of iron in cardiovascular disease still generates a fair amount of debate, due to a marked disparity in results.

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Section: Studies Finding An Association Between Iron and Cvdmentioning

confidence: 99%

Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial

et al. 2013

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“…Liao et al also observed that there was an inverse relationship between serum iron and MI risks in women [28]. Ekblom et al found that there exists a low risk for MI with iron levels in the normal upper range [29]. In a 6-month follow-up study done by Huang et al in STEMI patients who underwent angioplasty, low serum iron levels observed at the time of STEMI correlated with an increase in thrombolysis in myocardial infarction risk score after 6 months and also with inflammatory markers [30].…”

Section: Discussionmentioning

confidence: 96%

Correlation of Iron and Myeloperoxidase Levels in Ischemic Heart Disease

MUPPALA¹,

RAJESH²,

Patil

et al. 2020

Asian J Pharm Clin Res

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Objective: The objective of the study was to estimate, compare, and correlate serum iron and myeloperoxidase (MPO) levels in acute ischemic heart disease (IHD) cases. Methods: Subjects for the study were divided into two groups of 35 acute IHD cases and 35 age and sex matched controls. Serum iron and MPO levels were assayed, and results compared. Statistical analysis: The comparison between two groups was done using the Student’s t-test. Correlation between iron and MPO was established using Pearson’s correlation test. Results: High serum MPO levels and low iron levels were observed in acute IHD cases in comparison to controls. There was no significant correlation between serum iron and MPO in acute IHD cases. Conclusion: High iron levels have a beneficial role, whereas high MPO levels have an inflammatory role in the development of IHD. Determination of serum iron and MPO levels in high-risk subjects may help in taking proper measures to prevent acute IHD.

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“…Therefore, we bring attention to the results of Swedish prospective studies of risk for first myocardial infarction and first stroke, which assessed iron status as a possible risk factor for events by a combination of biomarkers of iron status and HFE (hemochromatosis) polymorphisms affecting iron status in nested casecontrol studies (3,4 ). The studies addressed specifically first-ever cases (most relevant from a public health perspective), by meticulous exclusion of individuals with prior diseases at recruitment, as well as controls who developed disease during the full follow-up period.…”

Section: To the Editormentioning

confidence: 99%