Iron status of newborns born to iron deficient anaemic mothers

Hokama, Tomiko; Takenaka, Shizuhiro; Hirayama, Kiyotake; Yara, Asao; Yoshida, Kaoru; Itokazu, Ken; Kinjho, Rieko; Yabu, Eri

doi:10.1093/tropej/42.2.75

Cited by 28 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The compensatory increase in FRmediated iron transport would be able to keep a constant iron supply from mother to fetus, although pregnant women with mild iron de®ciency and moderate iron de®ciency anemia have`inadequate' iron. It is probably the reason why iron status in fetuses whose mother is suffering from iron de®ciency is normal or nearly normal, as reported by some research groups (Gebre-Medhin & Birgegard, 1981;Dallman, 1989;Bhargava et al, 1991;Lao et al, 1991;Institute of Medicine, Food and Nutrition Board, 1993;Hokama et al, 1996). Our results also show that there is no signi®cant difference in FnRs between pregnant women with severe iron de®ciency anemia and with normal measurements.…”

Section: Discussionsupporting

confidence: 84%

“…However, the function of this compensatory system is believed to be limited based on the fact that the Tf saturation is remarkably decreased and the TfR expression is also hindered in pregnant women with severe iron de®ciency (Singla et al, 1996;Allen, 2000). In addition, it was reported that iron status in fetuses whose mothers were suffering from iron de®ciency is normal or nearly normal, being independent of maternal iron status (Gebre-Medhin & Birgegard, 1981;Dallman, 1989;Bhargava et al, 1991;Lao et al, 1991;Institute of Medicine, food and Nutrition Board, 1993;Hokama et al, 1996), although different results have been reported (Blot et al, 1999). These ®ndings imply that there might be some other mechanisms involved in the regulation of maternal-fetal iron transport.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation

et al. 2001

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: The effect of iron status in pregnant women on expression of ferritin receptor in placental microvilli membrane at mid-term gestation was investigated. Design: Ferritin receptor binding sites and dissociation constants (K d ) were determined in specimens of placental microvilli from 30 pregnant women at mid-term gestation and six women at term-delivery. Results: The ferritin receptor binding sites in the placental microvilli membrane in pregnant women with mild iron de®ciency and moderate iron de®ciency anemia were signi®cantly higher then those in pregnant women with normal iron status. However, no signi®cant difference was found between pregnant women with severe iron de®ciency anemia and with normal measurements. No signi®cant differences of K d values were detected between pregnant women with normal iron status and those with iron-de®ciency. Data also revealed that the ferritin receptor binding sites in placental microvilli membrane and K d values at mid-term gestation did not differ signi®cantly from those at term gestation. Conclusion: Lower iron status in pregnant women could lead to an increase in expression of ferritin receptor in placental microvilli membrane at mid-term gestation while the dissociation constant of ferritin receptor remains unchanged. This implies that the regulation of maternal ± fetal iron homeostasis via the ferritin receptor-mediated pathway is achieved by changes in the numbers of ferritin receptors rather then binding properties. Sponsorship: China Natural Science Foundation and The Hong Kong Polytechnic University. Descriptors: ferritin receptor; placental microvilli; iron status; pregnant women; maternal-fetal iron homeostasis

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation

et al. 2001

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…A recent Japanese study showed that a group of 16 mothers with iron de®ciency anaemia gave birth to infants with lower serum ferritin levels than those of non-iron de®cient mothers (Hokama et al, 1996), however, although a signi®cant proportion of the women were taking supplementary iron the study did not assess the diets of the women.…”

Section: Discussionmentioning

confidence: 99%

Diet during pregnancy in a population of pregnant women in South West England

1998

View full text Add to dashboard Cite

Objective: To describe the diet of a population of pregnant women. Subjects: Eleven thousand, nine hundred and twenty-three pregnant women resident in the south-west of England. Design: A self-completion unquanti®ed food-frequency questionnaire was sent to the women at 32 weeks gestation. Estimated daily nutrient intakes were calculated from the answers to the questionnaire. Results: On the whole, nutrient intakes of the pregnant women in this survey compared very closely with the reported nutrient intakes for all women aged 16±64 in the last Dietary and Nutritional Survey of British Adults (DNSBA). The exceptions were sugar, calcium, folate and vitamin C where the estimated intakes were somewhat higher, and retinol, where the estimated intake was somewhat lower than the DNSBA. Mean and median estimated nutrient intakes were above the RNIs for the majority of nutrients investigated except for energy, iron, magnesium, potassium and folate. Levels of supplementary vitamin and mineral use were fairly low, the two most commonly taken supplements were ironÐtaken by 22.5% of the pregnant women before 18 weeks and 43% at 32 weeks, and folate, taken by 9% and 18% of the women, respectively. Conclusions: These results suggest that the diets of pregnant women in this country are likely to contain adequate amounts of most nutrients, the most likely exceptions being iron, magnesium, potassium and folate.

show abstract

“…It is possible that there might be developmental effects on the infant, for example, a recent study with a very small number of subjects has shown that the infants of mothers with iron de®ciency anaemia are born with lower serum ferritin levels than those of iron-replete mothers, this may increase the risk of them developing anaemia subsequently (Hokama et al, 1996). The ALSPAC study is well placed to investigate this fully in a large cohort.…”

Section: Discussionmentioning

confidence: 99%

Financial difficulties, smoking habits, composition of the diet and birthweight in a population of pregnant women in the South West of England

et al. 1998

View full text Add to dashboard Cite

Objective: To investigate the relationships between self-assessed ®nancial dif®culties, diet in pregnancy and birthweight. Design: Information on diet composition, dif®culty in affording food, smoking habits and parity was collected by self-completion questionnaires at 32 weeks of pregnancy. Information on birthweights was obtained from hospital records. Subjects: A geographically de®ned population 11 833 pregnant women resident in the South-West of England. Main outcome measures: Nutrient intakes, food choices and birthweight. Results: Women with greater dif®culty in affording food had lower intakes of protein, ®bre, vitamin C, niacin, pyridoxine, iron, zinc, magnesium and potassium than did women with little or no dif®culty. They were more likely to use cooking and spreading fats with a high saturates content, and less likely to eat ®sh, fruit, vegetables and salad. In a multivariate analysis including parity and smoking status, ®nancial dif®culty was found to have no signi®cant relationship with birthweight. Conclusion: The quality of diet in pregnancy falls with increasing dif®culty in affording food. However, this does not appear to affect mean birthweight of infants born after 32 weeks gestation. Sponsor: The nutritional aspects of the study have been supported by Northern and Yorkshire regionÐNHS executive, Cow and Gate Ltd, the Meat & Livestock Commission and Coca-Cola UK. Descriptors: pregnancy; diet; nutrient intake; food choices; ®nancial dif®culties; smoking; birthweight IntroductionIn a 1995 report published by the National Children's Home and the Maternity Alliance (Dallison & Lobstein, 1995) the average weekly cost of an adequate diet for a pregnant woman was estimated at £18.12, almost half the income of a woman under 25 receiving bene®ts. However, in their survey of low-income pregnant women attending National Children's Home family centres 41% managed to spend less than £10 a week on food per family member, with many women regularly missing meals to save money. It has been suggested that the high incidence of lower than average birthweight among infants of these women might be partly attributable to a poor quality of diet during pregnancy.A number of studies have suggested that both the quantity and the quality of the diet in pregnancy may have an effect on birthweight (Rush, 1982;Olsen et al, 1986;Simmer et al, 1987;Doyle et al, 1990;Olsen et al, 1990). Low birthweight has a number of consequences, including an increased incidence of neonatal morbidity (Walther & Ramaekers, 1982) and mortality (Bakketeig et al, 1984). Furthermore, recent work from Professor Barker and his group has suggested that poor diet in pregnancy, as a result of poverty, may cause both low birthweight and metabolic programming in the fetus which is associated with an increased risk of a number of disorders such as cardiovascular disease (Barker & Fall, 1993;Barker et al, 1993b) and diabetes (Barker et al, 1993a) in adult life. Thus, if poor diets in pregnancy are adversely affecting birthweight at present this could repr...

show abstract

Iron status of newborns born to iron deficient anaemic mothers

Cited by 28 publications

References 0 publications

Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation

Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation

Diet during pregnancy in a population of pregnant women in South West England

Financial difficulties, smoking habits, composition of the diet and birthweight in a population of pregnant women in the South West of England

Contact Info

Product

Resources

About