Iron‐siRNA Nanohybrids for Enhanced Chemodynamic Therapy via Ferritin Heavy Chain Downregulation

Wang, Jun; Ding, Hongye; Yang, Zhu; Liu, Yina; Yu, Meili; Cai, Huilan; Ao, Rujiang; Huang, Hongwei; Gong, Peng; Liao, Yaxin; Chen, Zhaolin; Lin, Lisen; Chen, Xiaoyuan; Yang, Huanghao

doi:10.1002/ange.202302255

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…Nanozyme, nanoparticle endowed with inherent enzyme-mimic activities, has motivated the rapid advancement for novel tumor therapy strategy ( Huang Y. et al, 2019 ; Zhu et al, 2021a ; Tang et al, 2021 ; Zhu D. et al, 2022 ; Zhu et al, 2023 ). Nanozyme emerge as a promising candidate for regulating cellular bioprocesses due to their satisfactory enzymatic activities, excellent stability, cost-effectiveness, and superior membrane permeability compared to natural enzymes ( Zhu et al, 2021b ; Xu et al, 2022 ; Wang et al, 2023 ). A great deal of nanozymes have been reported to display impressive catalytic performances for cancer therapy ( Jiang et al, 2019 ; Zhu Y. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma

Wang,

Wu,

Wang

et al. 2024

Front. Chem.

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Numerous local herbal extract species have been investigated as potential medicinal ingredients due to their promising anti-cancer properties. However, the primary constraint of the class of plant flavonoids lies in their low solubility and limited membrane permeability, leading to chemical instability and restricted bioavailability that impede biomedical applications. In this study, we have developed an ideal nanozyme-Galazyme, comprising galangin-loaded copper Nanozyme coated by DSPE-PEG, which amplifies oxidative stress to induce apoptosis via the regulation of reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) activation. Galazyme exhibited significant peroxidase mimetic activity, demonstrating its potential to generate ROS and elevate oxidative stress. Upon uptake by HepG-2 cells, Galazyme efficiently converts excess hydrogen peroxide (H2O2) into highly reactive •OH radicals and upregulates MAPK expression, leading to the activation of Bax and Caspase 3, thereby promoting irreversible tumor cell apoptosis. Both in vitro and in vivo results demonstrate that Galazyme inhibits tumor cell growth and induces apoptosis by generating ample ROS and activating the MAPK pathway. Our study offers novel evidence supporting the enhancement of Galazyme-induced apoptosis through the upregulation of Bax and Caspase 3, along with the elucidation of the interaction between MAPK and apoptosis.

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Section: Introductionmentioning

confidence: 99%

Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma

Wang,

Wu,

Wang

et al. 2024

Front. Chem.

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show abstract

“…Nanozyme, nanoparticle endowed with inherent enzyme-mimic activities, has motivated the rapid advancement for novel tumor therapy strategy (Huang Y. et al, 2019;Zhu et al, 2021a;Tang et al, 2021;Zhu D. et al, 2022;Zhu et al, 2023). Nanozyme emerge as a promising candidate for regulating cellular bioprocesses due to their satisfactory enzymatic activities, excellent stability, costeffectiveness, and superior membrane permeability compared to natural enzymes (Zhu et al, 2021b;Xu et al, 2022;Wang et al, 2023). A great deal of nanozymes have been reported to display impressive catalytic performances for cancer therapy (Jiang et al, 2019;Zhu Y. et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Zhou,

Li,

et al. 2024

Advanced Materials

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Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, and producing anticancer microbial agents in situ to suppress tumor growth. Despite the unique advantages of bacteria‐based cancer biotherapy, the insufficient treatment efficiency limits its application in the complete ablation of malignant tumors. The combination of nanomedicine and engineered bacteria has attracted increasing attention owing to their striking synergistic effects in cancer treatment. Engineered bacteria that act as natural vehicles can effectively deliver nanomedicines to tumor sites. Moreover, bacteria provide an opportunity to enhance nanomedicines by modulating the TME and producing substrates to support nanomedicine‐mediated anticancer reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, and catalytic properties, and plays an important role in promoting bacteria‐mediated biotherapies. The synergistic anticancer effects of engineered bacteria and nanomedicines in cancer therapy are comprehensively summarized in this review. Attention is paid not only to the fabrication of nanobiohybrid composites, but also to the interpromotion mechanism between engineered bacteria and nanomedicine in cancer therapy. Additionally, recent advances in engineered bacteria‐synergized multimodal cancer therapies have also been highlighted.This article is protected by copyright. All rights reserved

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Iron‐siRNA Nanohybrids for Enhanced Chemodynamic Therapy via Ferritin Heavy Chain Downregulation

Cited by 4 publications

References 45 publications

Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma

Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma

DataSheet1.docx

Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

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