Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis
N. Ghatpande,
A. Harrer,
B. Azouly
et al.
Abstract:Acute bacterial orchitis (AO) is a prevalent cause of intra-scrotal inflammation, often resulting in sub- or infertility. A frequent cause eliciting AO is uropathogenic Escherichia coli (UPEC), a gram negative pathovar, characterized by the expression of various iron acquisition systems to survive in a low-iron environment. On the host side, iron is tightly regulated by iron regulatory proteins (IRP) 1 and 2 and these factors have been reported to play a role in testicular and immune cell function, however, th… Show more
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