“…Including our case, three other cases had cytologic specimens collected along with biopsy. Cytology specimens resulting from bronchial washings consistently revealed necro‐inflammatory exudates involving extra‐cellular golden‐brown fibrils . In two cases, reactive squamous cells were documented .…”
Section: Review Of the Literaturementioning
confidence: 96%
“…Cytology specimens resulting from bronchial washings consistently revealed necro‐inflammatory exudates involving extra‐cellular golden‐brown fibrils . In two cases, reactive squamous cells were documented . The presence of atypical squamous cells raised concerns for a squamous cells carcinoma in one case …”
Section: Review Of the Literaturementioning
confidence: 98%
“…In only 50% of the cases the aspiration event was noticed by the patient or recalled after a detailed clinical history taken retrospectively . The most frequent symptoms in the acute phase, defined as the first two weeks after the aspiration event, where coughing (53%), four patients presented with brown sputum and eight with obvious hemoptysis . Two cases presenting with hemoptysis were fatal due to massive lung haemorrhage .…”
Section: Review Of the Literaturementioning
confidence: 99%
“…Seventeen cases included chest X‐ray description, out of which six presented normal immediately after the episode of aspiration . On chest X‐ray, the abnormalities observed were non‐specific.…”
Section: Review Of the Literaturementioning
confidence: 99%
“…Bronchoscopy examinations performed in the acute phase, consistently revealed a yellow‐brown discolored, necrotic mucosa, occasionally forming a polypoid mass, markedly friable with easy bleeding when touched . Necrosis, inflammation, and pigments were reported to last up to two months …”
Iron pill-induced injury of bronchial mucosa is a complication following accidental aspiration of an iron tablet. Oral iron supplementation is a common therapy, particularly among advanced-age patients, who are more prone to aspiration. However, iron pill aspiration has been rarely reported in the literature, usually under the format of short case reports, with only 32 cases published in the literature. The cytologic features suspicious for this rare but potentially lethal entity have been seldom described. We report a case of a patient diagnosed with iron pill-induced bronchial injury, after oral ferrous sulfate has been prescribed during a hospital admission for pneumonia. In the bronchial washing specimen, a background of necrotic cell debris and acute inflammation involving extracellular golden-brown fibrils positive for iron stains was seen, along with the yeast forms, which, in this clinical context could confirm the iron pill aspiration. Our aim is to highlight the cytology features associated with iron pill aspiration bronchitis, and to review the literature for the histologic, clinical, bronchoscopy, and treatment aspects.
“…Including our case, three other cases had cytologic specimens collected along with biopsy. Cytology specimens resulting from bronchial washings consistently revealed necro‐inflammatory exudates involving extra‐cellular golden‐brown fibrils . In two cases, reactive squamous cells were documented .…”
Section: Review Of the Literaturementioning
confidence: 96%
“…Cytology specimens resulting from bronchial washings consistently revealed necro‐inflammatory exudates involving extra‐cellular golden‐brown fibrils . In two cases, reactive squamous cells were documented . The presence of atypical squamous cells raised concerns for a squamous cells carcinoma in one case …”
Section: Review Of the Literaturementioning
confidence: 98%
“…In only 50% of the cases the aspiration event was noticed by the patient or recalled after a detailed clinical history taken retrospectively . The most frequent symptoms in the acute phase, defined as the first two weeks after the aspiration event, where coughing (53%), four patients presented with brown sputum and eight with obvious hemoptysis . Two cases presenting with hemoptysis were fatal due to massive lung haemorrhage .…”
Section: Review Of the Literaturementioning
confidence: 99%
“…Seventeen cases included chest X‐ray description, out of which six presented normal immediately after the episode of aspiration . On chest X‐ray, the abnormalities observed were non‐specific.…”
Section: Review Of the Literaturementioning
confidence: 99%
“…Bronchoscopy examinations performed in the acute phase, consistently revealed a yellow‐brown discolored, necrotic mucosa, occasionally forming a polypoid mass, markedly friable with easy bleeding when touched . Necrosis, inflammation, and pigments were reported to last up to two months …”
Iron pill-induced injury of bronchial mucosa is a complication following accidental aspiration of an iron tablet. Oral iron supplementation is a common therapy, particularly among advanced-age patients, who are more prone to aspiration. However, iron pill aspiration has been rarely reported in the literature, usually under the format of short case reports, with only 32 cases published in the literature. The cytologic features suspicious for this rare but potentially lethal entity have been seldom described. We report a case of a patient diagnosed with iron pill-induced bronchial injury, after oral ferrous sulfate has been prescribed during a hospital admission for pneumonia. In the bronchial washing specimen, a background of necrotic cell debris and acute inflammation involving extracellular golden-brown fibrils positive for iron stains was seen, along with the yeast forms, which, in this clinical context could confirm the iron pill aspiration. Our aim is to highlight the cytology features associated with iron pill aspiration bronchitis, and to review the literature for the histologic, clinical, bronchoscopy, and treatment aspects.
Iron pill inhalation represents a uncommon cause of syntomatic endobronchial foreign bodies. Unlike foreign body, the direct contact of iron tablet onto the bronchial mucosa results in severe bronchial damage in addition to obstruction and local irritation. Four patients with Iron Pill Inhalation Syndrome are described. All but one patient developed irreversible bronchial stenosis as late post inflammatory complication. Bronchoscopic features and clinical evolution are described in order to reduce the risk of severe side-effects in patients highly suspected for iron pill aspiration.
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