Iron Oxide Nanoparticles Versus Ferrous Sulfate In Treatment of Iron Deficiency Anemia In Rats

Abstract

F errous sulfate is the most commonly used drug for treatment of iron deficiency anemia, but it is badly absorbed and causes many unfavorable side effects. Nanotechnology is a way to decrease the side effects of drugs and to increase the drug bioavailability. So, this study is designed to investigate the effect of iron oxide nanoparticles in comparison to ferrous sulphate in the treatment of iron deficiency anemia in rats. Forty male albino rats were divided into two main groups: Control group (10 rats) and anemic group (30 rats) that received standard iron free basal diet for six weeks. Then the anemic group was subdivided into three groups (10 rats) in each group: anemic control group, ferrous sulfate group (received ferrous sulfate 0.4 mg/ kg b.w/ 10 days) and iron oxide nanoparticles group (received iron oxide nanoparticles 0.4 mg/ kg b.w/ 10 days) in the drinking water. Iron oxide nanoparticlescaused a significant increase in the level of red blood cells (8.80±0.05 10 6 /µL), hemoglobin (18.46±0.33 g/dL), hematocrit (46.66±0.23 %), mean corpuscular volume (MCV) (53.02±0.3 FL), mean corpuscular hemoglobin concentration (MCHC) (39.56±0.6 %), ferritin (447.6±9.02 µg/L), transferrin saturation (138.0±1.5), total iron binding capacity (TIBC) (145.00±1.15 mg/dL) and serum iron (276.33±2.07 mg/dL). Moreover, it decreased serum malondialdehyde (MDA) (31.85±0.34 nmol/g) and C-reactive protein (CRP) (312.66±1.7 mg/L) when compared to ferrous sulfate group and anemia control groups. These results revealed that iron oxide nanoparticles proved as an effective drug for the treatment of iron deficiency anemia in rats.

Impact of Biscuit Fortified with Iron Nanoparticles as Food Supplement on Anemia in Albino Rat Model

“…Additionally, the ascorbic acid absorbed by the M cells and increase the bioavailability of nano-iron to perform it is a vital role. These data are in agreement with those reported by [44][45][46] The results of kidney functions such as urea, uric acid, and creatinine referred to as the fortified biscuit plays a vital role in IDA treatment due to its high nutritional value. Moreover, there was not any non-significate effect appeared on the kidney from iron oxide nanoparticles.…”

Biosynthesized Iron Oxide Nanoparticles from Petroselinum crispum Leaf Extract Mitigate Lead-Acetate-Induced Anemia in Male Albino Rats: Hematological, Biochemical and Histopathological Features

“…The current findings revealed a significant decrease in serum ferritin (iron store) and iron but an increase in TIBC in lead-acetate-induced anemic non-treated rats when compared to the negative control. The significant increase in TIBC could be due to the liver's increased production of transferrin in an attempt to maximize the utilization of the low available iron [57][58][59]. A similar result [60] showed that lead toxicity induced iron deficiency anemia by impairing heme biosynthesis.…”

Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats

“…It is necessary to develop new Fe supplements to increase Fe utilization and reduce its side effects ( 73 ). Nanotechnology is a means of decreasing the side effects while increasing its bioavailability ( 74 ).…”