Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization, and Application

Cotin, Geoffrey; Piant, Sébastien; Mertz, Damien; Felder‐Flesch, Delphine; Bégin‐Colin, Sylvie

doi:10.1016/b978-0-08-101925-2.00002-4

Cited by 47 publications

(33 citation statements)

References 200 publications

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“…Magnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) have a demonstrated efficiency in magnetic resonance imaging, drug delivery, bio-separation, catalysis and wastewater cleaning. Their efficiency as well as physical and chemical properties are influenced by their morphology, size and structure [ 92 ]. Currently applied techniques to synthesize MONP include thermal decomposition, co-precipitation and hydrothermal methods.…”

Section: Nanocellulose Hybrids With Magnetic Nanoparticlesmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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Cellulose is one of the most affordable, sustainable and renewable resources, and has attracted much attention especially in the form of nanocellulose. Bacterial cellulose, cellulose nanocrystals or nanofibers may serve as a polymer support to enhance the effectiveness of metal nanoparticles. The resultant hybrids are valuable materials for biomedical applications due to the novel optical, electronic, magnetic and antibacterial properties. In the present review, the preparation methods, properties and application of nanocellulose hybrids with different metal oxides nanoparticles such as zinc oxide, titanium dioxide, copper oxide, magnesium oxide or magnetite are thoroughly discussed. Nanocellulose-metal oxides antibacterial formulations are preferred to antibiotics due to the lack of microbial resistance, which is the main cause for the antibiotics failure to cure infections. Metal oxide nanoparticles may be separately synthesized and added to nanocellulose (ex situ processes) or they can be synthesized using nanocellulose as a template (in situ processes). In the latter case, the precursor is trapped inside the nanocellulose network and then reduced to the metal oxide. The influence of the synthesis methods and conditions on the thermal and mechanical properties, along with the bactericidal and cytotoxicity responses of nanocellulose-metal oxides hybrids were mainly analyzed in this review. The current status of research in the field and future perspectives were also signaled.

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Section: Nanocellulose Hybrids With Magnetic Nanoparticlesmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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“…In this regard, the surface modification of MNPs is a fundamental process for avoiding agglomeration and oxidation phenomena, such as Ostwald ripening, and improving stability and compatibility by providing interfacial electrostatic or steric repulsion forces between particles [ 77 , 78 ]. Additionally, surface functionalization enables the specific responses of nanoparticles to biological species and eliminates non-specific interactions with components within the system [ 90 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

“…There are two main methods of functionalizing MNPs’ surfaces, either by surface coating or surface grafting ( Figure 4 ) [ 31 ]. Surface coating is an effective way to prevent the dissolution of the nanoparticles, which further provides reactive functional groups for attaching various drugs, biomolecules, genes, or targeting ligands [ 78 , 90 ]. A variety of materials have been used for coating, including natural polymers (e.g., dextran, chitosan, pullulan, alginate, gelatin, agarose), synthetic polymers (e.g., polyethylene glycol, poly(ethylene-co-vinyl acetate), poly(vinylpyrrolidone), poly(lactic-co-glycolic acid), polyvinyl alcohol, polyacrylic acid, polyethyleneimine), organic surfactants, inorganic compounds, and bioactive molecules [ 70 , 77 , 78 , 88 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their efficiency. In this manner, systems comprising EOs and MNPs could offer potential solutions that could overcome the challenges associated with biofilm formation on prosthetic devices and antibiotic-resistant bacteria by ensuring a controlled and sustained release of the antibacterial agents.

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“…The bio-compatible and non-toxic maghemite (γ-Fe 2 O 3 ) and/or magnetite (Fe 3 O 4 ) phases have potential for thermal therapy, drug delivery and diagnostics via magnetic resonance imaging (MRI). [5][6][7][8] For MRI, IONPs in the range of 5 nm and smaller have recently attracted much attention as T 1 (positive) contrast agents. 8 Catalytic applications benefit from the high surface to volume ratio of IONPs and the possibility of magnetic recovery.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies demonstrated how small changes of the reaction conditions can change the particle characteristics, allowing to precisely control the IONP size 15,16,[18][19][20] and even shape. 5,21 One commonly used parameter to control the particle size is the heating rate, i.e., the temporal temperature increase to and above the precursor decomposition temperature. 18,22,23 The heating rate depends strongly on the experimental procedure and especially the size and geometry of the reaction vessel, which is why up-scaling using reactors of larger dimensions than standard lab-scale glassware is challenging.…”

Section: Introductionmentioning

confidence: 99%

Continuous production of iron oxide nanoparticles via fast and economical high temperature synthesis

et al. 2020

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Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization, and Application

Cited by 47 publications

References 200 publications

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Continuous production of iron oxide nanoparticles via fast and economical high temperature synthesis

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