Iron oxide nanoparticles based antiviral activity of H1N1 influenza A virus

Kumar, Rishikesh; Nayak, Malabika; Sahoo, Ganesh Chandra; Pandey, Krishna; Sarkar, Mamta Chawla; Ansari, Yousuf; Das, Vidya Nand Rabi; Topno, RK; Bhawna, -; Madhukar, Major; Das, Pradeep

doi:10.1016/j.jiac.2018.12.006

Cited by 150 publications

(85 citation statements)

References 36 publications

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“… [55] Iron oxide nanoparticles exert a potent antiviral activity against influenza virus strain A/H1N1 via the alteration of RNA transcription. [56] Iron oxide enzymes inactivate influenza A viruses and promote protection efficacy, possibly through peroxidation of viral lipid envelope. [57] …”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic

Gorji

Ghadiri

2021

Nutrition

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Highlights A robust immune response is crucial in the recovery COVID-19 infection. Micronutrients play a role in recruitment of immune responses (IR) to viral infections. Micronutrients deficiency (MD) contributes to the emergence of more virulent strains. MD and IR dysfunction may contribute to the morbidity of COVID-19 infection.

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Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic

Gorji

Ghadiri

2021

Nutrition

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“…Several studies have demonstrated the efficacy of metal NPs as potential antiviral agents against the influenza virus [143]. Iron oxide NPs showed in vitro inhibition (50%) against the H1N1 influenza A virus strain using a low concentration of 1.1 pg [143].…”

Section: Influenzamentioning

confidence: 99%

Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections

Maduray

Parboosing

2020

Biol Trace Elem Res

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Globally, viral diseases continue to pose a significant threat to public health. Recent outbreaks, such as influenza, coronavirus, Ebola, and dengue, have emphasized the urgent need for new antiviral therapeutics. Considerable efforts have focused on developing metal nanoparticles for the treatment of several pathogenic viruses. As a result of these efforts, metal nanoparticles are demonstrating promising antiviral activity against pathogenic surrogates and clinical isolates. This review summarizes the application of metal nanoparticles for the treatment of viral infections. It provides information on synthesis methods, size-related properties, nano-bio-interaction, and immunological effects of metal nanoparticles. This article also addresses critical criteria and considerations for developing clinically translatable nanosized metal particles to treat viral diseases.

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“…Polymer-functionalised gold NPs have been studied as efficient antiviral agents against HIV-1, H1N1, H3N2, H5N1 and dengue virus [46,47]. Iron oxide NPs (10−15 nm) have also been developed and tested against pandemic influenza virus strains A/H1N1/Eastern India/66/PR8-H1N1 with 50 % inhibition efficacy [48]. Single walled carbon nanotubes (of diameter 0.78 nm) also showed pronounced effects against influenza A virus infection in mice as shown by reduced lung injury, lower cytokine expression, and reduction of antiviral gene expression [49].…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Multivalent nanomedicines to treat COVID-19: A slow train coming

Tabish

Hamblin

2020

Nano Today

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The high transmission rate and serious consequences of the unprecedented COVID-19 pandemic make it challenging and urgent to identify viral pathogens and understand their intrinsic resistance mechanisms, to pave the way for new approaches to combat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Multivalent interactions are responsible for performing a broad range of biological functions in normal cells, such as cell-cell communication and adhesion. Multivalency underlies the reversibility of ligand-receptor interactions during infections. Previous studies into multivalent nanomedicines used against viruses, have revealed their ability, not only to probe the molecular processes of viral infections, but also to target pathogen-host cell binding with minimal collateral damage to normal cells. Nanomedicines are comparable in size to viruses and to cell receptor complexes (that mediate viral uptake), and can function as safe and accurate armoured vehicles to facilitate the transport of anti-viral drugs. Multivalent nanomedicines can be designed to avoid binding to extracellular serum proteins, and ultimately lead to destruction of the viruses. This brief perspective highlights the potential of innovative smart and safe multivalent nanomedicines that could target multiple viral factors involved in infections at cellular levels. For instance it is possible to target viral spike protein mediated entry pathways, as well as viral replication and cell lysis. Nanomedicine-based approaches could open new opportunities for anti-coronavirus therapies.

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Iron oxide nanoparticles based antiviral activity of H1N1 influenza A virus

Cited by 150 publications

References 36 publications

Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic

Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic

Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections

Multivalent nanomedicines to treat COVID-19: A slow train coming

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