Iron Oxide Nanoparticles as Contrast Agents in Molecular Magnetic Resonance Imaging

Ploussi, Agapi; Gazouli, Maria; Stathis, George; Kelekis, Nikolaos; Efstathopoulos, Efstathios

doi:10.1097/crd.0000000000000055

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…In recent years, some approaches previously used mainly for oncology imaging have been adapted to cardiovascular imaging, as it is the case of iron oxide nanoparticles, especially in the form of ultra-small supermagnetic iron oxide (USPIO) nanoparticles (<50 nm) (Ploussi et al, 2015 ). Early use of these NPs for medical imaging was described as a solution for the limiting factor in MRI, the background signal produced by the host tissue, but they can also be used for magnetic particle imaging (MPI), being capable of providing a higher sensitivity and a better spatial resolution (Gleich and Weizenecker, 2005 ).…”

Section: Nanoparticles In Therapeuticsmentioning

confidence: 99%

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

et al. 2018

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Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied using microscopy and spectroscopy techniques. In order to be effectively used, the physicochemical properties of nanoparticle formulations need to be taken into account, namely, particle size, surface charge distribution, surface derivatization and/or loading capacity, and related interactions. These properties need to be optimized considering the final nanoparticle intended biodistribution and target. In this review, we cover light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles. Dynamic light scattering is used to measure nanoparticles size, but also to evaluate their stability over time in suspension, at different pH and temperature conditions. Zeta-potential is used to characterize nanoparticles surface charge, obtaining information about their stability and surface interaction with other molecules. In this review, we focus on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.

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Section: Nanoparticles In Therapeuticsmentioning

confidence: 99%

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

et al. 2018

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“…The emergence of nanoparticles, which have been used for molecular imaging in targeting cancer cells, shows its essential possibility in aorta diseases (Gao et al, 2012). NP-based molecular imaging technologies have shown impressive efficacy by identifying some critical pathological processes during AAA (Sinha et al, 2014;Ploussi et al, 2015), which offers an exciting opportunity to eliminate the defect in our diagnosis approach beyond size and growth rate. For instance, gold nanoparticles (GNPs), as an ideal radiopaque CT contrast agent, have various advantages, including high density, high atomic number, high X-ray absorption coefficient, and low toxicity (Xi et al, 2012).…”

Section: Delivery Of Imaging Cues In Aortic Diseasesmentioning

confidence: 99%

Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases

Zhu

et al. 2020

Front. Bioeng. Biotechnol.

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The aorta is the largest artery in the body, so any diseases or conditions which could cause damage to the aorta would put patients at considerable and life-threatening risk. In the management of aortic diseases, the major treatments include drug therapy, endovascular treatment, and surgical treatment, which are of great danger or with a poor prognosis. The delivery of nano-biomaterials provides a potential development trend and an emerging field where we could monitor patients' conditions and responses to the nanotherapeutics. One of the putative applications of nanotechnology is ultrasensitive monitoring of cardiovascular markers by detecting and identifying aneurysms. Moreover, the use of nanosystems for targeted drug delivery can minimize the systemic side effects and enhance drug positioning and efficacy compared to conventional drug therapies. This review shows some examples of utilizing nano-biomaterials in in vitro organ and cell culture experiments and explains some developing technologies in delivering and monitoring regenerative therapeutics.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) are the base of contrast agents such as Ferumoxide and Ferucarbotan, examples of commercialized formulations that are widely used as T2-weighted contrast agents (negative agent) and are rapidly replacing gadolinium-based contrast agents because of the risk of nephrogenic systemic fibrosis (NSF) [ 3 , 4 , 5 ]. Molecular imaging is one of the most promising applications of SPIONs, and various applications have been evaluated in vitro and in animal experiments [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Heparin–Superparamagnetic Iron Oxide Nanoparticles for Theranostic Applications

et al. 2022

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In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were engineered with an organic coating composed of low molecular weight heparin (LMWH) and bovine serum albumin (BSA), providing heparin-based nanoparticle systems (LMWH@SPIONs). The purpose was to merge the properties of the heparin skeleton and an inorganic core to build up a targeted theranostic nanosystem, which was eventually enhanced by loading a chemotherapeutic agent. Iron oxide cores were prepared via the co-precipitation of iron salts in an alkaline environment and oleic acid (OA) capping. Dopamine (DA) was covalently linked to BSA and LMWH by amide linkages via carbodiimide coupling. The following ligand exchange reaction between the DA-BSA/DA-LMWH and OA was conducted in a biphasic system composed of water and hexane, affording LMWH@SPIONs stabilized in water by polystyrene sulfonate (PSS). Their size and morphology were investigated via dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. The LMWH@SPIONs’ cytotoxicity was tested, showing marginal or no toxicity for samples prepared with PSS at concentrations of 50 µg/mL. Their inhibitory activity on the heparanase enzyme was measured, showing an effective inhibition at concentrations comparable to G4000 (N-desulfo-N-acetyl heparin, a non-anticoagulant and antiheparanase heparin derivative; Roneparstat). The LMWH@SPION encapsulation of paclitaxel (PTX) enhanced the antitumor effect of this chemotherapeutic on breast cancer cells, likely due to an improved internalization of the nanoformulated drug with respect to the free molecule. Lastly, time-domain NMR (TD-NMR) experiments were conducted on LMWH@SPIONs obtaining relaxivity values within the same order of magnitude as currently used commercial contrast agents.

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Iron Oxide Nanoparticles as Contrast Agents in Molecular Magnetic Resonance Imaging

Cited by 10 publications

References 48 publications

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases

Heparin–Superparamagnetic Iron Oxide Nanoparticles for Theranostic Applications

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