Iron oxide nanoparticles and their pharmaceutical applications

Attia, Nour F.; El-Monaem, Eman M. Abd; El-Aqapa, Hisham G.; Elashery, Sally E.A.; Eltaweil, Abdelazeem S.; Kady, Misara El; Khalifa, Shaden A. M.; Hawash, Hamada B.; El‐Seedi, Hesham R.

doi:10.1016/j.apsadv.2022.100284

Cited by 51 publications

(22 citation statements)

References 151 publications

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“…Iron oxide (IO) (Fe 2 O 3 or Fe 3 O 4 ) nanoparticles have drawn prominence in variety of applications including biomedicine, water treatment, electronics and agriculture because of their their high biocompatibility, electrical, magnetic and optical properties [ [62] , [63] , [64] ]. In addition to these applications, antiviral efficacy of the IO nanoparticles is also reported via various mechanisms including binding ability to virus surface proteins and damaging of viral envelope, lipid peroxidation and ROS generation [ 26 ].…”

Section: Metal and Metal Oxide Nanoparticles Based Antiviral Surfaces...mentioning

confidence: 99%

Nanostructured coatings based on metallic nanoparticles as viral entry inhibitor to combat COVID-19

Singh

2023

Sustainable Materials and Technologies

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Section: Metal and Metal Oxide Nanoparticles Based Antiviral Surfaces...mentioning

confidence: 99%

Nanostructured coatings based on metallic nanoparticles as viral entry inhibitor to combat COVID-19

Singh

2023

Sustainable Materials and Technologies

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“…Among the different types of nanomaterials, MIO-NPs, and MIO-incorporated NCPs have drawn much attention in drug delivery due to their facile fabrication and surface functionalization, reusability, low toxicity, biocompatibility, and biodegradability [ 1 , 15 ]. In addition, the excellent magnetic properties of MIO-NP S endow them with extra proficiency over the other drug delivery systems, as represented by the therapeutic (e.g., magnetic targeting and hyperthermia) and diagnostic proficiencies (e.g., as a contrast agent in magnetic resonance imaging) [ 16 , 17 ]. Furthermore, due to the flexible surface chemistry of MIO-NPs, many drugs and bioactive molecules can be bound or loaded onto the surface, forming a drug-conjugated system [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, due to the flexible surface chemistry of MIO-NPs, many drugs and bioactive molecules can be bound or loaded onto the surface, forming a drug-conjugated system [ 18 ]. In addition, the unusual properties of many drugs, such as poor solubility, nonspecific delivery, and short circulating half-lives, can be overwhelmed by the incorporation of MIO-NPs [ 16 , 17 ]. These exclusive characteristics can be exploited in the development of nanomaterials suitable for medical and drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

“…As MIO-NPs have several unique advantages in the targeted drug delivery system, such as efficient drug solubility and stability, accurate dosage, drug release controllability, and effective delivery of therapeutics to specific sites with low toxicity and side effects [ 16 , 21 ], the incorporation of MIO-NPs into the cellulose matrix would produce excellent non-toxic NCPs, potentially expanding the application and opportunities in biomedicine and nanotechnology. In addition, the antioxidant profiling of a proposed drug delivery system is required to check whether the synthesized nanomaterials are capable of reducing reactive oxygen species (ROS) generation or not [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Magnetic Iron Oxide-Incorporated Cellulose Composite Particles: An Investigation on Antioxidant Properties and Drug Delivery Applications

et al. 2023

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In recent years, polymer-supported magnetic iron oxide nanoparticles (MIO-NPs) have gained a lot of attention in biomedical and healthcare applications due to their unique magnetic properties, low toxicity, cost-effectiveness, biocompatibility, and biodegradability. In this study, waste tissue papers (WTP) and sugarcane bagasse (SCB) were utilized to prepare magnetic iron oxide (MIO)-incorporated WTP/MIO and SCB/MIO nanocomposite particles (NCPs) based on in situ co-precipitation methods, and they were characterized using advanced spectroscopic techniques. In addition, their anti-oxidant and drug-delivery properties were investigated. Field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) analyses revealed that the shapes of the MIO-NPs, SCB/MIO-NCPs, and WTP/MIO-NCPs were agglomerated and irregularly spherical with a crystallite size of 12.38 nm, 10.85 nm, and 11.47 nm, respectively. Vibrational sample magnetometry (VSM) analysis showed that both the NPs and the NCPs were paramagnetic. The free radical scavenging assay ascertained that the WTP/MIO-NCPs, SCB/MIO-NCPs, and MIO-NPs exhibited almost negligible antioxidant activity in comparison to ascorbic acid. The swelling capacities of the SCB/MIO-NCPs and WTP/MIO-NCPs were 155.0% and 159.5%, respectively, which were much higher than the swelling efficiencies of cellulose-SCB (58.3%) and cellulose-WTP (61.6%). The order of metronidazole drug loading after 3 days was: cellulose-SCB < cellulose-WTP < MIO-NPs < SCB/MIO-NCPs < WTP/MIO-NCPs, whereas the sequence of the drug-releasing rate after 240 min was: WTP/MIO-NCPs < SCB/MIO-NCPs < MIO-NPs < cellulose-WTP < cellulose-SCB. Overall, the results of this study showed that the incorporation of MIO-NPs in the cellulose matrix increased the swelling capacity, drug-loading capacity, and drug-releasing time. Therefore, cellulose/MIO-NCPs obtained from waste materials such as SCB and WTP can be used as a potential vehicle for medical applications, especially in a metronidazole drug delivery system.

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“…Among the vegetable crops of great interest and importance is the pepper crop of the Mecca region, which is grown commercially. Recently, pepper plants have been used to evaluate the effects of antimicrobials and viruses [1] and to study the various plant defense mechanisms against viral infections [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Controlling Pepper Mild Mottle Virus (PMMoV) Infection in Pepper Seedlings by Use of Chemically Synthetic Silver Nanoparticles

2022

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We investigated the roles of different concentrations of chemical synthetic spherical silver nanoparticles (AgNPs) in protecting pepper seedlings of the Mecca region, which were naturally and artificially infected by the pepper mild mottle virus (PMMoV). The virus shows many infection symptoms, including pepper leaf deformation with filiform leaves and severe mosaic symptoms. Our study focused on the antiviral activity of different concentrations of spherical nanoparticles in controlling PMMoV infecting pepper seedlings. PMMoV identification was confirmed via DAS-ELISA using the following antiserum: PMMoV, cucumber mosaic virus (CMV), tobacco mosaic virus (TMV), tomato mosaic virus (ToMV), potato virus Y (PVY), and tomato spotted wilt virus (TSWV). The presence of PMMoV was confirmed using electron microscopy and reverse transcription polymerase chain reaction (RT-PCR). We evaluated the effects of exogenously applied different concentrations of AgNPs on CMV infection rate, infection severity, virus concentration, and the concentrations of photosynthetic pigments chlorophyll a, chlorophyll b, carotenoid content, phenolic compounds, and protein components in virus-infected plant cells that were treated with three different concentration of nanoparticles (200, 300, and 400 µg/L) compared to the positive and negative control.

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Iron oxide nanoparticles and their pharmaceutical applications

Cited by 51 publications

References 151 publications

Nanostructured coatings based on metallic nanoparticles as viral entry inhibitor to combat COVID-19

Nanostructured coatings based on metallic nanoparticles as viral entry inhibitor to combat COVID-19

Synthesis of Magnetic Iron Oxide-Incorporated Cellulose Composite Particles: An Investigation on Antioxidant Properties and Drug Delivery Applications

Controlling Pepper Mild Mottle Virus (PMMoV) Infection in Pepper Seedlings by Use of Chemically Synthetic Silver Nanoparticles

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