Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery

Ayyanaar, Srinivasan; Kesavan, Mookkandi Palsamy; Balachandran, C.; Rasala, Swetha; Rameshkumar, Perumal; Aoki, Shin; Rajesh, Jegathalaprathaban; Webster, Thomas J.; Rajagopal, Gurusamy

doi:10.1016/j.nano.2019.102134

Cited by 39 publications

(18 citation statements)

References 56 publications

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“…Gokduman synthesized magnetite iron oxide nanoparticles with a diameter of ∼20 nm, which could increase intracellular ROS, enhancing the anticancer activity of cisplatin by increasing the apoptosis of the cisplatin-resistant ovarian cancer cells (OVCAR-3 and SKOV-3) (Gokduman, 2019). Rajesh et al developed a hybrid magnetic microsphere system (Fe 3 O 4 @LEC-CUR-PLGA-MMS) using iron oxide nanoparticle (Fe 3 O 4 NP), lecithin (LEC), curcumin (CUR), PLGA, and polyethylene glycol (PEG) (Ayyanaar et al, 2020 hematite α-Fe 2 O 3 by wet chemical method, which showed dose-dependent anticancer activity against human metastatic ovarian cancer (OC) by inducing ROS generation, damaging the mitochondrial membrane, and triggering the apoptosis of OC PA-1 cells (Ramalingam et al, 2020). Pourahmad et al investigated the effect of SPIONs on the oral tongue squamous cell carcinoma (OTSCC) (Jahanbani et al, 2020).…”

Section: Intrinsic Fenton Reaction Of Ferritementioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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Ferrite nanoparticles have been widely used in the biomedical field (such as magnetic targeting, magnetic resonance imaging, magnetic hyperthermia, etc.) due to their appealing magnetic properties. In tumor acidic microenvironment, ferrite nanoparticles show intrinsic peroxidase-like activities, which can catalyze the Fenton reaction of hydrogen peroxide (H2O2) to produce highly toxic hydroxyl free radicals (•OH), causing the death of tumor cell. Recent progresses in this field have shown that the enzymatic activity of ferrite can be improved via converting external field energy such as alternating magnetic field and near-infrared laser into nanoscale heat to produce more •OH, enhancing the killing effect on tumor cells. On the other hand, combined with other nanomaterials or drugs for cascade reactions, the production of reactive oxygen species (ROS) can also be increased to obtain more efficient cancer therapy. In this review, we will discuss the current status and progress of the application of ferrite nanoparticles in ROS-mediated cancer therapy and try to provide new ideas for this area.

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Section: Intrinsic Fenton Reaction Of Ferritementioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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“…They are relatively novel drug delivery systems, having received attention from the early 1990s. In the early days of twentieth century, Paul Ehrlich envisioned his magic bullet concept-the idea that drugs reach the right site in the body, at the right time, at right concentration [25].…”

Section: Resultsmentioning

confidence: 99%

In vivo study on murine species using Cytarabine magnetic microspheres

Kakar

Jain

Singh

2020

IJPHS

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Cytarabine magnetic microspheres were formulated and checked for their antileukemic potential. Leukemia was persuaded in the Wister strain of rat by intravenous injection of benzene. Blood was procured and various hematological parameters were noted and compared. Animals were divided into four groups, antileukemial potential was found to be maximum in case of magnetic microspheres of Cytarabine. The study shows the Antileukemic potential of Cytarabine magnetic microspheres.

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“…57 A shoulder at 625 cm À1 indicated the formation of Fe-O-Si complexes through chemical binding between the FeO/ca-NPs and the SiO 2 shell. 26 In the case of FeO@SiO 2 -NH 2 , the broadband with low intensity between 3680 and 2916 cm À1 , 58 and the shoulder from 1335 to 1612 cm À1 , 59 were ascribed to the overlapping of the -OH bands by N-H bonds. The presence of amine groups on the surface was proved, suggesting a suitable surface for ds-DNA condensation.…”

Section: Nanostructures Synthesis and Characterizationmentioning

confidence: 97%