Iron oxide nanoclusters for T
            1 magnetic resonance imaging of non-human primates

Lu, Yang; Xu, Yun Jun; Zhang, Guo Bing; Ling, Daishun; Wang, Ming Quan; Zhou, Yong; Wu, Ya Dong; Wu, Tao; Hackett, Michael; Kim, Byung Hyo; Chang, Hogeun; Kim, Jong-Hoon; Hu, Xin; Dong, Liang; Lee, Jun Young; Li, Fangyuan; He, Jia; Zhang, Li; Wen, Hui Qin; Yang, Bo; Choi, Seung Hong; Hyeon, Taeghwan; Zou, Duo Hong

doi:10.1038/s41551-017-0116-7

Cited by 152 publications

(122 citation statements)

References 61 publications

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“…The magnetic nanoparticles have been widely applied to in vivo use, such as magnetic resonance imaging (MRI) [1][2][3], magnetic-induced hyperthermia [4,5], switching cellular activity [6][7][8], or magnetically guided drug/gene delivery [9][10][11]. Among them, MRI is one of the key applications in which magnetic nanoparticles are used as contrast-enhancing agents for improving the sensitivity of MRI.…”

Section: Introductionmentioning

confidence: 99%

Precise Study on Size-Dependent Properties of Magnetic Iron Oxide Nanoparticles for In Vivo Magnetic Resonance Imaging

Chen

Xie

et al. 2018

Journal of Nanomaterials

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Developing a biocompatible contrast agent with high stability and favorable magnetism for sensitive detection of malignant tumors using magnetic resonance imaging (MRI) remains a great demand in clinical. Nowadays, the fine control of magnetic iron oxide nanoparticle (MION) sizes from a few nanometers to dozens of nanometers can be realized through a thermal decomposition method of iron precursors. This progress allows us to research accurately on the size dependence of magnetic properties of MION, involving saturation magnetization (M s ), specific absorption rate (SAR), and relaxivity. Here, we synthesized MION in a size range between 14 and 26 nm and modified them with DSPE-PEG2000 for biomedical use. The magnetic properties of PEGylated MION increased monotonically with MION size, while the nonspecific uptake of MION also enhanced with size through cell experiments. The MION with the size of 22 nm as a T2-weighted contrast agent presented the best contrastenhancing effect comparing with other sizes in vivo MRI of murine tumor. Therefore, the MION of 22 nm may have potential to serve as an ideal MRI contrast agent for tumor detection.

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Section: Introductionmentioning

confidence: 99%

Precise Study on Size-Dependent Properties of Magnetic Iron Oxide Nanoparticles for In Vivo Magnetic Resonance Imaging

Chen

Xie

et al. 2018

Journal of Nanomaterials

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Section: Introductionmentioning

confidence: 99%

“…The fast advances of nanomedicine and nanotechnology provide diverse theranostic nanoplatforms for efficient diagnostic imaging and therapeutic applications, and some promising nanosystems have entered either the clinical trial or practical application stages . For instance, these nanoplatforms act as the contrast agents for disease imaging, which can substantially improve the imaging sensitivity and resolution of the lesion cell/tissue . In addition, some kinds of nanoplatforms have been generally designed as the nanovectors for directly delivering the therapeutic agents, such as anticancer drug or therapeutic gene molecules, into the diseases, by which the therapeutic efficacy can be enhanced and the side effects can be simultaneously mitigated .…”

Section: Introductionmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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“…The particle size is influenced to the structural characteristics namely the lattice symmetry and cell parameter) as well as electronic properties in any material. Metal oxide nanocluster finds its promising applications in optical and sensors [1], optoelectronics [2], photocatalysts [3] and biomedical applications [4]. Till now, there have been a considerable number of reports for the fabrication of various metal oxide nanocluster, such as ZnO [5][6][7][8], TiO 2 [1,3,9], SnO 2 [10][11][12][13], In 2 O 3 [14][15][16], CuO 2 [17][18][19], WO 3 [20,21].…”

Section: Introductionmentioning

confidence: 99%

Effect of Annealing on Metal-Oxide Nanocluster

Singh¹,

Rajkumari²

2019

Concepts of Semiconductor Photocatalysis

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Recently, the development of optoelectronic devices based on metal-oxide nanocluster has attracted intensive research interest. Nanoclusters are suitable for these because of their large surface-to-volume ratio and the presence of abundant oxygen vacancies or trap states. Metal-oxides such as ZnO, In 2 O 3 , and TiO 2 synthesized using different technique produces high surface area films consisting of clusters and provides complete control over the film morphology. In this chapter, some of the metal oxides nanocluster film has investigated, and the effect of annealing on the structural, optical and electrical properties of the grown films when subjected to different annealing temperatures will be studied. Theoretically, these properties are presumed to improve after the heat treatment as the crystallinity, and the grain size of the film has increased due to the diminishing of oxygen vacancies. Thus, the greater surface-to-volume ratio, the better stoichiometry and higher level of crystallinity compared to bulk materials make nanocluster-based devices very promising for the mentioned application.

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Iron oxide nanoclusters for T 1 magnetic resonance imaging of non-human primates

Cited by 152 publications

References 61 publications

Precise Study on Size-Dependent Properties of Magnetic Iron Oxide Nanoparticles for In Vivo Magnetic Resonance Imaging

Precise Study on Size-Dependent Properties of Magnetic Iron Oxide Nanoparticles for In Vivo Magnetic Resonance Imaging

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Effect of Annealing on Metal-Oxide Nanocluster

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