Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models

Santos, Leonardo dos; Rodrigues, Sabrina Bertoli; Ávila, Renata Andrade; Marques, Vinícius Bermond

doi:10.1016/j.bbagen.2022.130172

Cited by 10 publications

(5 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animals from UA displayed blood Fe approximately four to five times higher than the range of concentrations reported for other species previously studied (Humphries et al, 2022; Lemaire et al, 2022). Excess iron accumulation can lead to tissue damage and oxidative stress in animals (Clauss & Paglia, 2012; Dos Santos et al, 2022), and further studies exploring this increase in blood Fe in animals from UA and TR are important.…”

Section: Discussionmentioning

confidence: 99%

Nondestructive Evaluation of Metal Bioaccumulation and Biochemical Biomarkers in Blood of Broad‐Snouted Caiman (Caiman latirostris) from Northeastern Brasil

dos Santos,

Mariz Jr.,

Mascarenhas‐Júnior

et al. 2024

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Studies on the bioaccumulation and toxicity of contaminants in Crocodylians are scarce. We evaluated alterations in concentrations of the nondestructive biomarkers butyrylcholinesterase (BChE), glutathione‐S‐transferase (GST), superoxide dismutase (SOD), and reduced glutathione (GSH), together with bioaccumulation of the metals iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), chronium (Cr), aluminium (Al), and lead (Pb) in Caiman latirostris captured in Tapacurá Reservoir (TR; São Lourenço da Mata, Pernambuco, Brasil), in urbanized areas of Pernambuco State (UA; Brasil) and from the AME Brasil caiman farm (AF; Marechal Deodoro, Alagoas, Brasil); the latter was used as a potential reference with low levels of contamination. For metal analysis, 500 µL of blood was digested in 65% HNO3 and 30% H2O2. The samples were analyzed by inductively coupled plasma–optical emission spectrometry. For analysis of biomarkers, an aliquot of blood was centrifuged to obtain plasma in which biochemical assays were performed. Blood concentrations of metals analyzed in animals from AF were lower compared with TR and UA, confirming that animals from the caiman farm could be used as references with low levels of contamination. Iron, Cu, Mn, Al, and Pb exceeded toxic levels for other vertebrates in animals from TR and UA. Butyrylcholinesterase activity showed significant reduction in adults from UA and TR compared with AF. An increase in the activity of GST and GSH, in adults of TR and UA in relation to AF, was verified. Superoxide dismutase activity showed a significant reduction in adults of TR in relation to AF, and the concentrations of Cu and Mn were negatively correlated with SOD activity. Animals from UA and TR showed greater concentrations of the analyzed metals compared with reference animals, and changes in biomarkers were seen, confirming the potential of these nondestructive chemical and biological parameters in blood of C. latirostris for biomonitoring of pollution. Environ Toxicol Chem 2024;00:1–18. © 2024 SETAC

show abstract

Section: Discussionmentioning

confidence: 99%

Nondestructive Evaluation of Metal Bioaccumulation and Biochemical Biomarkers in Blood of Broad‐Snouted Caiman (Caiman latirostris) from Northeastern Brasil

dos Santos,

Mariz Jr.,

Mascarenhas‐Júnior

et al. 2024

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Oral or IV Fe supplementation increases hemoglobin concentration and thus prevents and treats all forms of anemia ( 6 , 8 – 10 ). However, Fe overload increases the level of oxidative stress in the human body ( 20 ) and increases the risk of developing other diseases during pregnancy, such as GDM ( 12 ) and preeclampsia ( 21 ). Moreover, long-term periconceptional Fe supplementation of more than 30 mg/d was associated with increased GDM risk in a large prospective cohort of pregnant Chinese women ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of serum concentrations of metal nutrients with postpartum anemia among pregnant Chinese women: A large retrospective cohort study

Chen

Pang

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

Background and AimsThe association between serum concentrations of metal nutrients in pregnancy and postpartum anemia has not been widely studied. This study aimed to determine this association in a large retrospective cohort study.MethodsWe included 14,829 Chinese women with singleton pregnancies. Serum concentrations of metals before 28 weeks of gestation, the occurrence of postpartum anemia and other potential covariates were obtained from their laboratory or medical records. Cox regression and restricted cubic spline regression models were used to explore the relationship between serum concentrations of metal nutrients in pregnancy and postpartum anemia.ResultsAfter adjustment for covariates, higher concentrations of iron (Fe), magnesium (Mg) and zinc (Zn) and lower concentrations of copper (Cu) were associated with a lower risk of postpartum anemia. Compared with those whose serum concentrations of metal nutrients were in the bottom quintile (Q1), the hazard ratios (HRs) of those whose serum concentrations of metal nutrients were in the top quintile (Q5) were 0.57 (95% confidence interval (CI): 0.50, 0.64) for Fe, 0.67 (95% CI: 0.60, 0.76) for Mg, 0.82 (95% CI: 0.73, 0.93) for Zn, and 1.44 (95% CI: 1.28, 1.63) for Cu. L-shaped curve relationships were found between increasing concentrations of Fe, Mg, and Zn and incidence of postpartum anemia. Higher serum concentrations of Cu were associated with an increased risk of postpartum anemia. Serum concentrations of Fe in Q5 were associated with a lower risk of postpartum anemia when they coincided with serum concentrations of Mg in Q5, Zn in Q5, or Cu in Q1.ConclusionHigher serum concentrations of Fe, Mg, and Zn, and lower serum concentrations of Cu were associated with a lower risk of postpartum anemia among pregnant women.

show abstract

“…4 ). Catalytically active iron is involved in producing reactive oxygen species (ROS) and promoting lipid peroxidation, which is crucial in the development of atherosclerosis [ 63 ]. Iron overload is often observed in macrophages and endothelial cells in atherosclerotic lesions.…”

Section: Iron Overload and Cvdmentioning

confidence: 99%

Iron Dysregulation in Cardiovascular Diseases

Wang,

Huang,

et al. 2024

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Iron metabolism plays a crucial role in various physiological functions of the human body, as it is essential for the growth and development of almost all organisms. Dysregulated iron metabolism—manifested either as iron deficiency or overload—is a significant risk factor for the development of cardiovascular disease (CVD). Moreover, emerging evidence suggests that ferroptosis, a form of iron-dependent programed cell death, may also contribute to CVD development. Understanding the regulatory mechanisms of iron metabolism and ferroptosis in CVD is important for improving disease management. By integrating different perspectives and expertise in the field of CVD-related iron metabolism, this overview provides insights into iron metabolism and CVD, along with approaches for diagnosing, treating, and preventing CVD associated with iron dysregulation.

show abstract

Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models

Cited by 10 publications

References 118 publications

Nondestructive Evaluation of Metal Bioaccumulation and Biochemical Biomarkers in Blood of Broad‐Snouted Caiman (Caiman latirostris) from Northeastern Brasil

Nondestructive Evaluation of Metal Bioaccumulation and Biochemical Biomarkers in Blood of Broad‐Snouted Caiman (Caiman latirostris) from Northeastern Brasil

Associations of serum concentrations of metal nutrients with postpartum anemia among pregnant Chinese women: A large retrospective cohort study

Iron Dysregulation in Cardiovascular Diseases

Contact Info

Product

Resources

About