Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice

Ferroptosis as an emerging target in sickle cell disease

“…It also suppresses L-2-hydroxyglutarate (L2HG) production, a metabolite implicated in epigenetic modifications and the regulation of genes linked to metabolic processes, oxidative stress, and ferroptotic responses ( Xi et al, 2023 ). Pharmacological activation of NRF2 shows protective effects against ROS stress and ferroptosis in SCD models ( Fan et al, 2017 , Chauhan and Zennadi, 2023 , Duarte et al, 2023 ), highlighting the NRF2-SLC7A11-GPX4 axis as a promising therapeutic target in conditions marked by iron overload and oxidative stress, such as in SCD ( Shakya et al, 2023 ). Particularly, leonurine, a natural alkaloid, has shown hepatoprotective benefits in SCD by reducing iron-induced hepatotoxicity, primarily through suppressing ferroptosis and reducing oxidative damage and inflammation.…”