Iron Overload Cardiomyopathy in Clinical Practice

Fe2+ Block and Permeation of CaV3.1 (α1G) T-Type Calcium Channels: Candidate Mechanism for Non–Transferrin-Mediated Fe2+ Influx

“…Iron levels normally are tightly regulated in the body (Zhang and Enns, 2009). Increased intracellular iron levels have been associated with disorders involving the heart (Horwitz and Rosenthal, 1999;Kremastinos and Farmakis, 2011) and the brain (Stankiewicz and Brass, 2009), including neurological disorders such as amyotrophic lateral …”

Short Communication: High Cellular Iron Levels Are Associated with Increased HIV Infection and Replication

“…32 The increased cellular iron levels observed in our studies may be a consequence of virus attempting to establish a favorable environment for its own replication. As tissue iron accumulation is seen in many HIV-associated diseases, including neurodegeneration and diastolic cardiac dysfunction, [33][34][35][36][37] it is tempting to speculate that altered cellular iron homeostasis secondary to HIV infection may, at least partially, contribute to the organ damage associated with HIV infection.…”

The Iron Paradigm of Pulmonary Arterial Hypertension

“…For example, high levels of iron in the myocardium could result in iron-overload cardiomyopathy. 26 As iron metabolism varies among tissues, the precise mode of delivery, ensuring repletion in the lung while avoiding overload in the heart or other organs, may be a clinical challenge.…”