IRON NOF trial: IV iron for anaemic patients with femoral fracture

Associations between postoperative anaemia and unplanned readmission to hospital after major surgery: a retrospective cohort study†

“…This finding corresponded with a reduced odds ratio (95%CI) of readmission in the intravenous iron group at the same time‐point (0.61 (0.4–0.9)). A similar pattern of haemoglobin incrementation (no difference immediately, but a significant difference emerging between groups at postoperative day 30 or 90) has been replicated in other interventional trials and observational studies in different surgical cohorts [9, 10, 19, 20], suggesting the benefits of iron therapy or an iron‐replete state are not seen immediately after surgery but instead take some weeks to become apparent [21].…”

“…Although an attractive therapeutic target, pre-operative anaemia is multifactorial and treatment can be logistically difficult before surgery, particularly when surgical treatment is urgent [6]. Interventional trials assessing the role of pre-operative intravenous iron suggest the greater effect may be after surgery [7][8][9][10], particularly to prevent unplanned readmission [11]. Changing the focus of treatment to the postoperative period may yield greater benefits.…”

Post-operative Anaemia Independently Predicts Prolonged Hospital Length of Stay After Upper Gastrointestinal Cancer Surgery

“…[3][4][5] These include pre-operative optimization through prehabilitation, anemia prevention, neo-adjuvant/adjuvant chemotherapy, radiation and/or palliative therapy and surgery. [6][7][8][9][10][11][12][13][14] There are increasing evidence demonstrating multidisciplinary prehabilitation programs that improve functional capacity before surgery may reduce hospital LOS after cancer surgery. [15][16][17][18][19] Prolonged length of stay (LOS) occurs in approximately 10% of patients undergoing major upper GI surgery and is associated with higher risks of readmission, postoperative complications, and mortality.…”