Iron, Nitrogen-Doped Carbon Aerogels for Fluorescent and Electrochemical Dual-Mode Detection of Glucose

Abstract

Due to their effective catalytic activity and maximum atom utilization, single metal atoms dispersed in carbon matrices have found diverse applications in electrocatalysis, photocatalysis, organic catalysis, and biosensing. Herein, iron is atomically dispersed into nitrogen-doped porous carbon aerogel by a facile pyrolysis procedure, and the resulting nanocomposite behaves both as a peroxidase mimic for the sensitive detection of glucose by fluorescence spectroscopy and as an effective catalyst for the electrochemical oxidation of glucose. The glucose concentration can be quantified within the millimolar to micromolar range with a limit of detection of 3.1 and 0.5 μM, respectively. Such a dual-functional detection platform also shows excellent reproducibility, stability, and selectivity, and the performance in glucose detection of clinical and artificial human body fluids is highly comparable to that of leading assays in recent studies and results from commercial sensors. Results from this study suggest that carbon aerogel-supported single atoms can be used as a dual-functional nanozyme for the construction of low-cost, high-performance dual-signal readout platforms for glucose detection.

Mechanism and Application of Surface-Charged Ferrite Nanozyme-Based Biosensor toward Colorimetric Detection of l-Cysteine

“…Because of the development of nanotechnology, biotechnology, and catalytic mechanism, researchers have obtained a deeper understanding of nanozymes. In addition to the magnetic Fe 3 O 4 nanoparticles, other kinds of materials also possess enzyme-like catalytic properties, including but not limited to iron-based materials, , precious-metal materials, , carbon-based materials, , metal sulfides, , metal–organic frameworks, and so on. , At present, the enzyme-like properties of nanozymes have expanded from peroxidase-like properties , to catalase-like, − oxidase, , superoxide dismutase, − lactic acid enzyme, and other different properties.…”

Single-atom catalysts for photocatalytic energy conversion

“…44,[71][72][73] CO 2 reduction,45,62,[74][75][76] N 2 reduction,63,77,78 C-O coupling,65 pollutant degradation, 79,80 CH 4 conversion,68 H 2 O 2 production,69 as well as photocatalytic sensing 70,81,82. …”

Enhancing H2O2and glucose double detection by surface microstructure regulation of Brussels sprout-like Ni–Co(OH)2/rGO/carbon cloth composites

“…8b and Table S3, ESI †). [43][44][45][46][47][48] Fig. 7d reveals the CVs of the Ni-Co(OH) 2 /rGO3/CC electrode with different scan rates from 50 to 300 mV s À1 .…”