Iron Nanowires Coated with Metal–Organic Frameworks for Cell-Type-Specific Multimodal Therapy

Abstract

Targeted therapy has the potential to revolutionize medical approaches to bring us closer to an effective personalized therapy model. In this work, we developed homologous-targeted magnetic nanowires coated with biologics-loaded zeolitic imidazolate frameworks and cellular membranes (ZNWs) to provide an increased therapeutic potential both in vitro and in vivo. In vitro, the uncoated ZNWs combined with laser treatment reduced cancer cell viability by 34.6%, whereas the coated ZNWs combined with laser treatment reduced cancer cell viability by 45.91%. In vivo, ZNWs accumulated selectively in MCF-7 cancer cells and maintained a high intensity for up to 120 h, which reduced tumor growth significantly. Combining gene and tumor ablation treatment with the homologous targeting ability of ZNWs resulted in about 73% cell death. We believe that using such an assembled coating to camouflage delivery vehicles has effective outcomes in terms of improved targeting and therapeutic efficiency and should be studied further for medical translation.

Molecular Nanotechnology for Tomorrow’s World: A Forum Dedicated to Professor Sir Fraser Stoddart on the Occasion of His 80th Birthday

“…20 Khashab and co-workers prepared magnetic nanowires coated with biologics-loaded zeolitic imidazolate frameworks and cellular membranes for multimodal cancer therapy. 21 In another work, Ronconi et al prepared pillar [5]arene-gated mesoporous silica for the responsive cargo release to tumor cells. 22 Riela and co-workers integrated a halochromic switch with halloysite nanotubes for the detection of cancer cells.…”

“…Forgan et al developed glycopolymer-functionalized MOF-808 nanoparticles for the cancer-targeted codelivery of carboplatin and floxuridine drugs, showing a high cytotoxicity to HepG2 human hepatocellular carcinoma cells . Khashab and co-workers prepared magnetic nanowires coated with biologics-loaded zeolitic imidazolate frameworks and cellular membranes for multimodal cancer therapy . In another work, Ronconi et al prepared pillar[5]­arene-gated mesoporous silica for the responsive cargo release to tumor cells .…”