Iron Mobilisation and Cellular Protection by a New Synthetic Chelator O-Trensox

Rakba, Nafissa; Aouad, Fouad; Henry, Christophe; Caris, Catherine; Morel, Isabelle; Baret, Paul; Pierre, Jean‐Louis; Brissot, Pierre; Ward, Roberta J.; Lescoat, Gérard; Crichton, Robert R.

doi:10.1016/s0006-2952(98)00009-4

Cited by 32 publications

(22 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, iron has opposite effects on HAMP gene expression in cultured as compared to freshly isolated hepatocytes [6,8]. It is well known that FAC is toxic to hepatocytes in culture [33]. However, in our model a general toxic effect of FAC can be ruled out as the only explanation for the decreased HAMP expression, since the expression of IREG1 increased as expected in response to FAC (Fig.…”

Section: Discussionsupporting

confidence: 49%

Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes

Dzikaite

Holmström

Stål

et al. 2006

Journal of Hepatology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 49%

Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes

Dzikaite

Holmström

Stål

et al. 2006

Journal of Hepatology

View full text Add to dashboard Cite

“…In ferritin-loaded hepatocytes, DFO and Trensox are nearly equally effective at mobilizing 55 Fe, most of which may be expected to be stored in ferritin [185]. In vivo, Trensox is as effective as DFO in mobilizing iron from overloaded rats [185].…”

Section: O-trensoxmentioning

confidence: 99%

“…In vivo, Trensox is as effective as DFO in mobilizing iron from overloaded rats [185]. Trensox causes the release of Fe from ferritin in a cell-free system, although it does so less efficiently than DFO [185].…”

Section: O-trensoxmentioning

confidence: 99%

The Role of Iron Chelation in Cancer Therapy

Buss¹,

Torti²,

Torti³

2003

CMC

214

216

View full text Add to dashboard Cite

This review focuses on advances and strategies in the use of iron chelators as anti-tumor therapies. Although the development of iron chelators for human disease has focused primarily on their use in the treatment of secondary iron overload, chelators may also be useful anti-tumor agents. They can deplete iron or cause oxidative stress in the tumor due to redox perturbations in its environment. Iron chelators have been tested for their anti-tumor activity in cell culture experiments, animal models and human clinical trials. Largely for pragmatic reasons, clinical studies of the anti-tumor activity of iron chelators have generally focused on desferrioxamine (DFO), a drug approved for the treatment of iron overload. These studies have shown that DFO can retard tumor growth in many different experimental contexts. However, the activity of DFO is modest, and advances in the use of chelators as anti-cancer agents will require the development of new chelators based on new paradigms. Examples of iron chelators that have shown promising anti-tumor activity (in various stages of development) include heterocyclic carboxaldehyde thiosemicarbazones, analogs of pyridoxal isonicotinoyl hydrazone, tachpyridine, O-trensox, desferrithiocin, and other natural and synthetic chelators. Apart from their use as single agents, chelators may also synergize with other anti-cancer therapies. The development of chelators as anticancer agents is largely an unexplored field, but one with extraordinary potential to impact human cancer.

show abstract

“…For instance, DFO has been demonstrated to induce apoptosis in a number of cancer cell lines including ovarian cancer, 202 neuroblastoma, 203 Kaposi's sarcoma, 122 malignant oral keratinocytes 169 and cervical carcinomas. 204 Other chelators, including Triapine, 205 311, 90 Tachpyridine, 132,206,207 O-Trensox 208 and Dp44mT 93 have also been shown to induce apoptosis in a variety of neoplastic cell types both in vitro and in vivo.…”

Section: The Molecular Targets Of Iron Chelators and Their Effects Onmentioning

confidence: 99%