Iron metabolismin conditions of infection. Review

Orlov, Yuriy P.; Govorova, Natalia; Лукач, В Н; Baitugaeva, G.A.; Klementyev, A.V.; Kakulya, E.N.

doi:10.21320/1818-474x-2020-1-90-99

Cited by 6 publications

(1 citation statement)

References 65 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disorders of iron metabolism), resulting in the release of free iron ions into the blood plasma, the extracellular space and inside cells. Free iron activates the free-radical oxidation of biological membrane lipids that is accompanied by toxic damage of proteins and cell structures (Lukina and Dezhenkova, 2015;Orlov, 2020) and is also a potential energy source for pathogens (Orlov, 2020). The prime targets for iron toxicity are the liver, endocrine system, and myocardium (Tarasova and Teplyakova, 2012).…”

Section: Introductionmentioning

confidence: 99%

Experimental Study of Steel Shot and Lead Shot Transformation Under the Environmental Factors

Lisin¹,

Chizhikova²,

Lubkova³

et al. 2022

Preprint

View full text Add to dashboard Cite

This paper presents the results of an experimental study of the patterns of steel and lead shot transformation under the impact of environmental factors (two types of shot exposed alone and in combination with each other). The analyzed environmental factors include atmospheric precipitation of various acidity and soil solutions with a higher content of organic acids. This research demonstrated that steel shot is characterized by a high transformation rate that is an order of magnitude higher on average than the transformation rate of lead under the same conditions. The prevalence of the suspended iron form (excluding the interaction with organic acids) presents risks for such environmental components as soils and sediments and may be hazardous to the ambient air and natural waters in case of wind erosion and surface runoff from the catchment area. Furthermore, the joint presence of steel and lead shot mutually accelerates the corrosion of both metals, thus increasing the environmental risks.

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental Study of Steel Shot and Lead Shot Transformation Under the Environmental Factors

Lisin¹,

Chizhikova²,

Lubkova³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Rationale and design of the open-label, prospective, randomized study of the efficacy of intravenous versus oral iron deficiency therapy in improving left ventricular systolic function in patients with myocardial infarction (OPERA-MI)

et al. 2022

View full text Add to dashboard Cite

Aim. Iron has a protective effect on cardiomyocytes during hypoxia, while iron deficiency (ID) directly affects its function, disrupting mitochondrial respiration, reducing their contractility and relaxation. Some studies have shown that ID is a predictor of adverse outcomes in patients with acute coronary syndrome (ACS). However, the impact of ID and its treatment, quality of life and prognosis of patients with ID and myocardial infarction (MI) has not been fully established. The study aim is to determine the effectiveness of intravenous ferric carboxymaltose (FCM) compared with oral iron (ferrous sulfate) in relation to left ventricular (LV) systolic function, assessed by echocardiography.Material and methods. This open-label, prospective, randomized study includes 360 patients with or without ID who were hospitalized with acute myocardial infarction (MI). Patients with ID will be randomized (1:1) to intravenous FCM and oral ferrous sulfate therapy. Treatment in groups will be started at the time of hospitalization. Patients without ID will form the control group. The follow-up period for patients will be 1 year. The primary endpoint was a reduction in LV wall motion score index (WMSI) in the FCM group compared to the ferrous sulfate group. The key secondary endpoint is a composite endpoint of cardiovascular death, non-fatal MI and stroke, and hospitalization for decompensated heart failure.Conclusion. The OPERA-MI study will determine the effect of ID treatment with intravenous FCM compared with oral ferrous sulfate on WMSI, which reflects LV systolic function.

show abstract

Iron deficiency in patients with coronary artery disease

Khastieva

Khasanov

2022

Russ J Cardiol

View full text Add to dashboard Cite

A number of studies have demonstrated the negative impact of iron deficiency (ID) on the prognosis and course of heart failure. The prevalence of patients with coronary artery disease (CAD) in these studies was 39,4-65%, while the proportion of patients who had myocardial infarction reached 60%. The effect of ID on CAD course requires further study. The aim of this review was to analyze the available data on the effect of ID on heart function, quality of life, and prognosis in patients with CAD. This literature review analyzed 359 publications and systematized information on ID prevalence in patients with CAD, pathophysiological effects of ID on the function and structure of cardiomyocytes, the impact of ID on the course, prognosis, and quality of life in patients with CAD. The influence of ID and its correction on cardiomyocytes and left ventricular systolic function were studied.

show abstract

Iron metabolismin conditions of infection. Review

Cited by 6 publications

References 65 publications

Experimental Study of Steel Shot and Lead Shot Transformation Under the Environmental Factors

Experimental Study of Steel Shot and Lead Shot Transformation Under the Environmental Factors

Rationale and design of the open-label, prospective, randomized study of the efficacy of intravenous versus oral iron deficiency therapy in improving left ventricular systolic function in patients with myocardial infarction (OPERA-MI)

Iron deficiency in patients with coronary artery disease

Contact Info

Product

Resources

About