Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula

Effect of Lactoferrin Supplementation on Iron Deficiency Anemia in Primary School Children

“…This consisted with the study of Paesano et al [13] , who study Lf versus iron (ferrous sulphate) in management of iron deficiency and IDA and reported that, mean iron level before treatment was ≤30 mg/dl, that elevated to 84±16 mg/dl after treatment for 30 days. Also, results coincides with the study of Ke et al [14] who reported significant increase in iron absorption in exclusively breastfed infants after supplementation with Lf-fortified milk. Also, results in agreement with the study held by Bethell and Huang [15] .…”

Dose Effect of Bovine Lactoferrin Fortification on Iron Metabolism of Anemic Infants

“…No significant difference in linear growth changes (including weight, length, and HC) was observed among anemic infants after 3 mo of bLF fortification, which was not in agreement with another study (26) and our previous results (17). Some studies have observed that bLF treatment significantly increased the weight, height, or HC gains of infants due to bLF-promoted cell proliferation and differentiation (27), increased total protein content of the treatment formula (by about 5%) (14), or reduced prevalence of diarrhea, upper respiratory tract infection, and anemia (17).…”

“…The anemic infants with an average daily intake of 47.2 mg bLF showed similar changes in Hb as compard with the anemic infants receiving no fortified bLF after the 1 and 3 mo of intervention. Our previous study (17) reported that daily intake of 35.8 mg bLF significantly increased the Hb level in healthy infants when compared to infants fed no additional bLF from the formula. Chierici et al (13) showed that there were no statistically significant differences in Hb and haematocrit between different feeding groups (exclusively breastfeeding, formula feeding with 0, 10 mg/100 mL and 100 mg/100 mL bLF) at any sampling time, however, the dosage of bLF was not reported in this study.…”

“…Studies have explored the effect of bLF on iron absorption of infant and suggested that formula fortified with bLF could significantly increase hematocrit, serum ferritin (SF), and reticulocyte levels (11)(12)(13)(14)(15)(16). Our previous study (17) also indicated that formula fortified with 38 mg/100 g of bLF positively affected the hemoglobin (Hb) and iron status of infants who were previously exclusively breastfed and suggested that the effects of bLF fortification on iron metabolic homeostasis were mainly exerted through promoting total body iron E-mail: 263662086@qq.com content (TBIC) and iron absorption in intestine. However, most of the subjects in our previous study were in good health and their Hb concentrations were above the defined Hb levels of anemia.…”

Growth stimulating effect of bovine milk lactoferrin on dermal cells and probiotic bacteria

“…Therapeutic capabilities of bovine lactoferrin (bLF) allow us to consider it as an active basis for medical preparations and therapeutic food products (Yoo et al, 1997;Fotschki et al, 2015;García-Tejedor et al, 2015a and2015b;Ke et al, 2015). Currently, in the Russian Federation there is a perspective to solve the problem of domestic production of bLF by intensive growth of waste-free processing of raw milk through the implementation of innovative developments, especially baromembrane and nanotechnologies (Khramtsov, 2010 and2015).…”