Iron metabolism in human pregnancy as studied with the radioactive isotope, Fe59

Hahn, P. F.; Carothers, E. L.; Darby, William J.; Martin, Margaret P.; Sheppard, C. W.; Cannon, Richard O.; Beam, A.S.; Densen, Paul M.; Peterson, John C.; McClellan, George S.

doi:10.1016/0002-9378(51)91394-4

Cited by 120 publications

(30 citation statements)

References 8 publications

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“…One can suggest that during the last weeks of preg nancy, there is an equilibrium between sup plies and needs in women whose diet is roughly normal. This equilibrium can be maintained not only as a result of maternal iron stores but also by increased iron diges tive absorption [15,16].…”

Section: Discussionmentioning

confidence: 99%

Iron Supplements versus Placebo during Pregnancy: Its Effects on Iron and Folate Status on Mothers and Newborns

et al. 1983

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Iron and folate status of 203 pregnant women have been evaluated at 6 months gestation and on the same women and their newborn infants at delivery. The women who had, at 6 months gestation, a Hb level below 11 g/dl were systematically given iron supplements. Iron or placebo were randomly allocated to the other women. At 6 months of pregnancy, one quarter of the women had a Hb level under 11 g/dl but one third had a serum ferritin level below 12 µg/l and more than half had low levels of serum and red cell folate. Iron supplements induced an increase both in Hb levels and in serum ferritin values; however, no significant differences were observed in serum ferritin of the newborn infants, whether their mothers had received iron supplements or not. These results have led us to reconsider the value of ferritin levels at birth as an index of iron stores in the infant. Iron supplements had no effect on the folate status in mothers or infants or on the frequency of obstetrical complications. A significant relationship was found between maternal folate levels and length of gestation. Folate supplementation may reduce the incidence of premature delivery.

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Section: Discussionmentioning

confidence: 99%

Iron Supplements versus Placebo during Pregnancy: Its Effects on Iron and Folate Status on Mothers and Newborns

et al. 1983

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“…Iron and certain vitamins, such as B12 and folate, may be exceptions. It has been shown that the proportion of radioactive iron absorbed from a radioactively labeled dose increases twofold during gestation (Hahn et al, 1951;Heinrich et al, 1968). Similarly, the attained blood levels of B12 and folate after an oral dose of these vitamins is higher in pregnant than in nonpregnant women (Hellegers et al, 1957;Chanarin et al, 1959).…”

Section: 1 Alimentary Functionsmentioning

confidence: 98%

Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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“…However, there is a lack of evidence on the alternatives to high-dose iron supplements to treat anaemia in pregnancy. Because iron absorption is influenced by iron stores (The British Nutrition Foundation, 1995) and iron dose (Hahn et al, 1951;The British Nutrition Foundation, 1995), the amount absorbed increases with lower iron stores and lower iron doses. Therefore, the difference in the actual amounts of iron absorbed from high-dose vs low-dose iron supplements may be insignificant and low-dose iron supplements may be adequate to treat anaemia in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose–response trial

et al. 2007

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Background/Objectives: To compare the efficacy and side effects of low-dose vs high-dose iron supplements to correct anaemia in pregnancy. Subjects/Methods: One hundred and eighty women with anaemia (haemoglobin o110 g l À1 ) in mid-pregnancy. The women were randomly allocated to 20; 40 or 80 mg of iron daily for 8 weeks from mid-pregnancy. Results: One hundred and seventy-nine (99%) women completed the trial. At the end of treatment, there was a clear doseresponse of increasing mean haemoglobin concentration with iron dose (111713 g l À1 at 20 mg per day, 114711 g l À1 at 40 mg per day and 119712 g l À1 at 80 mg per day, P ¼ 0.006). However, the incidence of anaemia did not differ statistically between groups. Compared with women in the 80 mg iron group, the odds ratio of anaemia was 1.9 (95% CI: 0.8, 4.3, P ¼ 0.130) and 1.1 (95% CI: 0.5, 2.6, P ¼ 0.827), respectively, for women in the 20 mg iron group and the 40 mg iron group. The incidence of gastrointestinal side effects was significantly lower for women in the 20 mg iron group compared with women in the 80 mg iron group; the odds ratio was 0.4 (95% CI: 0.2, 0.8, P ¼ 0.014) for nausea, 0.3 (95% CI: 0.2, 0.7, P ¼ 0.005) for stomach pain and 0.4 (95% CI: 0.2, 0.9, P ¼ 0.023) for vomiting. Conclusions: Low-dose iron supplements may be effective at treating anaemia in pregnancy with less gastrointestinal side effects compared with high-dose supplements.

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Iron metabolism in human pregnancy as studied with the radioactive isotope, Fe59

Cited by 120 publications

References 8 publications

Iron Supplements versus Placebo during Pregnancy: Its Effects on Iron and Folate Status on Mothers and Newborns

Iron Supplements versus Placebo during Pregnancy: Its Effects on Iron and Folate Status on Mothers and Newborns

Nutrition and Pregnancy

Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose–response trial

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