Iron-mediated allylation of aryl aldehydes in aqueous media

Iron Catalysis in Organic Synthesis

“…The group of Chan elaborated an iron mediated procedure for the allylation of aryl aldehydes with allyl bromide in water. 974 However, it required stoichiometric amounts of iron powder and sodium fluoride for its activation.…”

A Practical Catalyst‐Free Synthesis of 6‐Amino‐4 Alkyl/Aryl‐3‐methyl‐2,4‐dihydropyrano[2,3‐c]pyrazole‐carbonitrile in Aqueous Medium

“…With recent emphasis on development of green methodology, organic synthesis in water [23][24][25][26][27][28][29] is getting a lot of importance. Water is proven as a very good solvent [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] for many organic reactions and has its share of advantages, such as safety, cost, environmental concerns, unique redox stability, high heat capacity [45], and product isolation over conventional organic solvents. With the pioneering discovery by Breslow [46] on the role of water in rate acceleration of Diels-Elder reaction between nonpolar compounds in homogeneous organic solutions, various reports of "in-water" and "on-water" organic reactions have surfaced leading to generation of curiosity over the mechanistic insight of such reactions.…”

Sn/I2 Mediated allylation of carbonyl compounds with allyl (crotyl) halide in water

“…Metals such as indium 2 , zinc 3 , gallium 4 , iron 5 and tin 6 are always used as mediators. However, in order to improve the reaction yield, more than stoichiometric amount of metals, long reaction time, the vast use of inorganic salt 7 (e.g.…”