Iron Lung Treatment of Subjects with COPD in Acute Respiratory Failure

Corrado, Antonio; G, Bruscoli; Messori, Andrea; Ghedina, Laura; Nutini, S.; Paola, E De; Baccini, A

doi:10.1378/chest.101.3.692

Cited by 32 publications

(17 citation statements)

References 10 publications

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“…All relapses of ARF during follow-up were treated by NPV. The survival rates after 1 and 5 yrs were 82 and 37%, respectively [85]. The survival observed in our patients was better than that reported previously in COPD patients with ARF submitted to conventional mechanical ventilation [90].…”

Section: Arf In Copd With Chronic Respiratory Insufficiencycontrasting

confidence: 46%

“…Tank ventilators [25,84,85] and ponchowrap [26,86] have been used to deliver NPV in COPD patients with ARF (table 2). In all these studies, NPV was provided in control mode.…”

Section: Arf In Copd With Chronic Respiratory Insufficiencymentioning

confidence: 99%

“…The authors concluded that NPV permits increased oxygen flow in patients with severe hypercapnic respiratory failure due to advanced COPD, and prevents the need, in some cases, of more aggressive ventilatory support [86]. NPV used as a first-line of treatment in severe COPD patients with ARF was found to be associated with a good outcome and long-term prognosis [85]. In this uncontrolled report, 105 COPD patients with chronic respiratory insufficiency admitted to our respiratory intensive care unit from 1976 to 1980 for ARF were retrospectively evaluated.…”

Section: Arf In Copd With Chronic Respiratory Insufficiencymentioning

confidence: 99%

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Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered

Corrado¹,

Gorini²,

Villella³

et al. 1996

European Respiratory Journal

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Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered. A. Corrado, M. Gorini, G. Villella, E. De Paola. ©ERS Journals Ltd 1996. ABSTRACT: Noninvasive mechanical ventilatory techniques include the use of negative and positive pressure ventilators. Negative pressure ventilators, such as the "iron lung", support ventilation by exposing the surface of the chest wall to subatmospheric pressure during inspiration; whereas, expiration occurs when the pressure around the chest wall increases and becomes atmospheric or greater than atmospheric.In this review, after a description of the more advanced models of tank ventilators and the physiological effects of negative pressure ventilation (NPV), we summarize the recent application of this old technique in the treatment of acute respiratory failure (ARF). Several uncontrolled studies suggest that NPV may have a potential therapeutic role in the treatment of acute on chronic respiratory failure in patients with chronic obstructive pulmonary disease and restrictive thoracic disorders, reducing the need for endotracheal intubation. In the paediatric field, after substantial technical improvement, NPV has been successfully reintroduced for the treatment of ARF due to neonatal distress syndrome and bronchopulmonary dysplasia, and for the weaning from positive pressure ventilation in intubated patients.The positive results of these reports need to be formally confirmed by further prospective and controlled studies before recommending the generalized use of negative pressure ventilation in acute respiratory failure as a standard of care.

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Section: Arf In Copd With Chronic Respiratory Insufficiencycontrasting

confidence: 46%

“…Tank ventilators [25,84,85] and ponchowrap [26,86] have been used to deliver NPV in COPD patients with ARF (table 2). In all these studies, NPV was provided in control mode.…”

Section: Arf In Copd With Chronic Respiratory Insufficiencymentioning

confidence: 99%

Section: Arf In Copd With Chronic Respiratory Insufficiencymentioning

confidence: 99%

See 1 more Smart Citation

Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered

Corrado¹,

Gorini²,

Villella³

et al. 1996

European Respiratory Journal

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“…In the literature, survival rates at one year of patients who underwent invasive mechanical ventilation ranged 34-49% in different studies, [18][19][20]. The only long-term study on noninvasively ventilated patients [21] showed a survival rate at 1 yr very much higher than in other studies on patients treated conventionally either with medical therapy alone or by endotracheal mechanical ventilation. CORRADO and coworkers [22] used a negative pressure ventilation mode, the iron lung, to administer early treatment to COPD patients with acute respiratory failure (ARF) and at any relapse of ARF.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive mechanical ventilation improves the immediate and long-term outcome of COPD patients with acute respiratory failure

Confalonieri¹,

Parigi²,

Scartabellati³

et al. 1996

Eur Respir J

107

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N No on ni in nv va as si iv ve e m me ec ch ha an ni ic ca al l v ve en nt ti il la at ti io on n i im mp pr ro ov ve es s t th he e i im mm me ed di ia at te e a an nd dl lo on ng g--t te er rm m o ou ut tc co om me e o of f C CO OP PD D p pa at ti ie en nt ts s w wi it th h a ac cu ut te e r re es sp pi ir ra at to or ry y f fa ai il lu ur re e M. Confalonieri*, P. Parigi*, A. Scartabellati*, S. Aiolfi*, S. Scorsetti*, S Nava**, L. Gandola* In-hospital survival rate was not significantly different in Group A vs Group B, but the patients treated with NPPV showed an earlier improvement in blood gases and a better pH and respiratory rate at discharge. Only 2 patients of Group A needed endotracheal intubation as compared with 9 of Group B. Hospital stay was significantly reduced in survivors of Group A vs Group B. Further severe relapses of ACRF in Group A were treated using NPPV. The number and length of further hospitalizations for pulmonary exacerbations were significantly higher in Group B compared with Group A. The survival rate at 12 months was significantly lower in Group B than in Group A (50% vs 71%).In conclusion, NPPV administration in patients with ACRF due to exacerbated COPD improves not only immediate but also long-term outcome.

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“…In 1996, a comprehensive review examining the literature on this topic was published [1]. NPV does not have the same body of randomised controlled trial data to support its use in acute-on-chronic respiratory failure, but there have been seven uncontrolled studies [2][3][4][5][6][7][8] and two case controlled studies [9,10]. The studies have often been of large numbers of patients, and recently, the preliminary results of two randomised controlled trials comparing NPV with both invasive mechanical ventilation and mask ventilation have been reported in abstract form [11,12].…”

mentioning

confidence: 99%