Iron Load and Liver Enzymes in 10‐ and 13‐year‐olds

Okuda, Masayuki; Sasaki, Satoshi; Kunitsugu, Ichiro; Sakurai, Ryuta; Yoshitake, Norikazu; Hobara, Tatsuya

doi:10.1097/mpg.0b013e318201aecc

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…The association was no longer significant in models adjusted for transaminases. Raised transaminases commonly run in parallel to increased serum ferritin levels, even in pediatric populations . The mechanisms underlying this association are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Iron Status and Metabolically Unhealthy Obesity in Prepubertal Children

Suárez‐Ortegón

Echeverri

Prats‐Puig

et al. 2019

Obesity

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Objective This study aimed to evaluate the association of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) with iron status markers in prepubertal children. Methods Three hundred twelve prepubertal children with overweight and obesity from a pediatric general Spanish population were evaluated. MHO and MUO were defined as obesity with the absence or presence of metabolic syndrome components. Phenotypes of metabolically healthy overweight including obesity (MHOV) and metabolically unhealthy overweight including obesity (MUOV) were also studied and defined using the same criteria. Serum ferritin, transferrin, and blood hemoglobin levels were evaluated. Results Prevalence rates of MHOV and MHO were 35% (n = 111/312) and 27.1% (n = 42/155), respectively. Ferritin and hemoglobin levels were higher in children with MUOV versus MHOV (P < 0.05). MUO was positively associated with ferritin (beta [95% CI] = 0.43 [0.05 to 0.81]) and hemoglobin levels (0.43 [0.05 to 0.81]). These associations remained significant independently of age, sex, C‐reactive protein, physical activity, and BMI/waist z scores in bivariate linear regression models. In multivariable models, transaminase levels attenuated the association of MUO with ferritin and hemoglobin levels (P > 0.05). Conclusions MUOV and MUO are associated with higher ferritin and hemoglobin levels in prepubertal children affected by overweight and obesity. Increased circulating ferritin in MUO might be influenced by liver injury.

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Section: Discussionmentioning

confidence: 99%

Iron Status and Metabolically Unhealthy Obesity in Prepubertal Children

Suárez‐Ortegón

Echeverri

Prats‐Puig

et al. 2019

Obesity

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“…Excess iron ultimately leads to its accumulation in macrophages and subsequently in hepatocytes promoting oxidative stress (Gutteridge and Halliwell, 1989). Increased iron level in prepubertal and pubertal children has been demonstrated to be implicated in increased alanine aminotransferase activity (Okuda et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Second-hand tobacco smoke and children

Al-Sayed

Ibrahim

2012

Toxicol Ind Health

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Cigarette smoke contains harmful chemicals with hazardous adverse effects on almost every organ in the body of smokers as well as of nonsmokers exposed to environmental tobacco smoke (ETS). There has been increasing interest in the effects of passive smoking on the health of children. In order to detect the magnitude of passive smoking in children, parental questionnaires, measuring nicotine and cotinine body levels, and evaluating expired carbon monoxide (CO) concentrations, have been used. Passive smoking causes respiratory illness, asthma, poor growth, neurological disorders, and coronary heart diseases. Herein, we focused on the deleterious influences of passive smoking on immunity and liver. Besides, its effects on the concentrations of various biomarker levels related to the oxidant/antioxidant status were considered. Understanding these effects may help clinicians to counsel parents on smoking cessation and smoke exposure elimination. It may also help to develop interventions to improve the health of children. This review potentially demonstrated some nutraceuticals with a promising role in the prevention of smoking-related diseases.

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