Iron Intake Influences Essential Fatty Acid and Lipid Composition of Rat Plasma and Erythrocytes

Cunnane, Stephen C.; McAdoo, Kelly R.

doi:10.1093/jn/117.9.1514

Cited by 58 publications

(28 citation statements)

References 23 publications

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“…Some investigators have observed lipemia when anemia was produced by iron-deficient diets (1)(2)(3). Moreover, hepatic lipogenesis measured by means of 14 Cglucose incorporation was altered in livers of severely irondeficient chicks and rats (2,3), and the fatty acid composition of tissues changed as a result of nutritional iron depletion (4)(5)(6)(7). However, within these experiments, the results from one study often contradicted those from another.…”

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confidence: 99%

Different degrees of moderate iron deficiency modulate lipid metabolism of rats

Stangl

Kirchgeßner

1998

Lipids

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Severe iron deficiency affects lipid metabolism. To investigate whether moderate iron depletion also alters lipid variables-including lipid levels in serum and liver, hepatic lipogenesis, and fatty acid composition indicative of an impaired desaturation-we carried out experiments with rats fed 9, 13, and 18 mg iron/kg diet over a total of 5 wk. The study also included three pair-fed control groups and an ad libitum control group, fed with 50 mg iron/kg diet. The iron-depleted rats were classified as iron-deficient on the basis of reduced serum iron, hemoglobin concentration, and hematocrit. All moderately iron-deficient rats had significantly lower cholesterol concentrations in liver and serum lipoproteins than their pair-fed controls. Rats with the lowest dietary iron supply had higher concentrations of hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE), lower activities of glucose-6-phosphate dehydrogenase, malic enzyme and fatty acid synthase, and higher triacylglycerol concentrations in serum lipoproteins than the corresponding pair-fed control rats. Moderate iron deficiency also depressed the serum phospholipid level. Moreover, several consistent significant differences in fatty acid composition of hepatic PC and PE occurred within moderate iron deficiency, which indicate impaired desaturation by delta-9 and delta-6 desaturases of saturated and essential fatty acids. We conclude that lipid variables, including cholesterol in liver and serum lipoproteins as well as fatty acid desaturation, reflect the gradations of iron status best and can be used as an indicator of the degree of moderate iron deficiency.

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confidence: 99%

Different degrees of moderate iron deficiency modulate lipid metabolism of rats

Stangl

Kirchgeßner

1998

Lipids

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“…This effect was not due to altered rates of diet consumption or weight gain and suggests the involvement of regulatory mechanisms. Previous studies showed a converse relationship between iron and lipid metabolism [22,23] . Since lack of hepcidin expression causes iron overload, elevated hepatic iron content may have interfered with fat accumulation in HFS-fed knockout mice.…”

Section: Discussionmentioning

confidence: 93%

“…The mechanisms by which excess iron contribute to NAFLD pathogenesis is unclear. Although inconclusive, some studies suggested a role for iron in the regulation of lipid metabolism [23][24][25] . Since hepcidin is the central regulator of iron metabolism, we investigated its role in fatty liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…Studies with genetic haemochromatosis (GH) patients have shown the association of primary iron overload with fibrogenesis [22] . By using dietary experimental models, some studies have also suggested a reverse connection between iron and steatosis in rat livers [23,24] . In contrast, another study with a mouse dietary model of iron and high fat failed to show any significant effect of iron on steatosis [25] .…”

Section: Introductionmentioning

confidence: 99%

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Lack of hepcidin expression attenuates steatosis and causes fibrosis in the liver

Bennett

Kharbanda

et al. 2016

WJH

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“…Both clinical and experimental studies prove that iron deficiency has an adverse effect on the metabolism of polyunsaturated fatty acids [1,2]. A low serum content of total polyunsaturated fatty acids was found in children with moderate anemia [3].…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acid Plasma Content in Groups of General Population with LowVitamin B<sub>6</sub> or Low Iron Serum Levels

Krajcovicová-Kudlácková

Klvanová

Dušinská

2004

Ann Nutr Metab

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Experimental and human studies describe the adverse effect of iron or vitamin B₆ deficiencies on polyunsaturated fatty acid metabolism. Iron is present in end proteins of the δ6-desaturase enzyme complex, and vitamin B₆ deficiency can affect the transmethylation reaction of proteins. Plasma polyunsaturated fatty acid content was estimated in apparently healthy subjects of the general population with no consumption of fish and low vitamin B₆ serum levels (<3 µg/l; n = 21) or with low iron serum levels (men: <12 µmol/l; women: <10 µmol/l; n = 16) and compared to a control group (n = 22) with normal vitamin B₆ and iron serum levels (in reference range). The activities of the δ6-desaturase enzyme complex were calculated as product/precursor (conversion indices). In groups of subjects with low vitamin B₆ and low iron levels, δ6-desaturase activity together with δ5-desaturase activity (conversion of α-linolenic/18:3,n–3/ into eicosapentaenoic acid/20:5,n–3/) as well as the conversion index of docosahexaenoic acid formation (22:6,n–3) from 22:5,n–3 (second δ6-desaturase activity) were significantly reduced. The inhibition effect on fatty acid synthesis was more pronounced in subjects with low iron levels than in those with low vitamin B₆ levels. The conversion indices correlated significantly positively with vitamin B₆ or iron levels.

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Iron Intake Influences Essential Fatty Acid and Lipid Composition of Rat Plasma and Erythrocytes

Cited by 58 publications

References 23 publications

Different degrees of moderate iron deficiency modulate lipid metabolism of rats

Different degrees of moderate iron deficiency modulate lipid metabolism of rats

Lack of hepcidin expression attenuates steatosis and causes fibrosis in the liver

Polyunsaturated Fatty Acid Plasma Content in Groups of General Population with LowVitamin B<sub>6</sub> or Low Iron Serum Levels

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