Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues

Valenzuela, Rodrigo; Rincón‐Cervera, Miguel Ángel; Echeverría, Francisca; Barrera, Cynthia; Espinosa, Alejandra; Hernández-Rodas, María Catalina; Ortíz, Macarena; Valenzuela, Alfonso; Videla, Luis A.

doi:10.1016/j.nut.2017.07.007

Cited by 42 publications

(40 citation statements)

References 52 publications

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“…Since they often appear to be modulated by ATC and ω-3 PUFA in an opposite way, it would be worthwhile to investigate their involvement in future combined studies examining the effects ω-3 PUFA and ATC at CV level. Remarkably, it has been recently observed that one of the consequences of iron overload at the hepatic level is the inhibition of the Δ-5 and Δ-6 desaturases, which prevents the endogenous synthesis of LC-ω-3 PUFA, and leads to their depletion with harmful consequences for the cells [ 131 ]. Since iron overload is also considered one of the main mechanisms of ATC-induced cardiotoxicity, it would be stimulating to investigate whether it may suppress the synthesis and the level of LC-ω-3 PUFA also at cardiac levels, and if the impaired synthesis could be related to ATC-cardiotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

Serini

Vasconcelos

Gomes

et al. 2017

IJMS

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It has been demonstrated that ω-3 polyunsaturated fatty acids (ω-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of ω-3 PUFA in different kinds of cancers, and several human studies have shown that ω-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects. ω-3 PUFA have also been shown to prevent harmful side-effects (including cardiotoxicity and heart failure) induced by conventional and innovative anti-cancer drugs in both animals and patients. The available literature regarding the possible protective effects of ω-3 PUFA against anthracycline-induced cardiotoxicity, as well as the mechanisms involved, will be critically discussed herein. The study will analyze the critical role of different levels of ω-3 PUFA intake in determining the results of the combinatory studies with anthracyclines. Suggestions for future research will also be considered.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

Serini

Vasconcelos

Gomes

et al. 2017

IJMS

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“…Δ‐5 and Δ‐6 desaturases), availability of specific nutrients (e.g. zinc), redox cell state (especially hepatic), hormones, and genetics (Burns et al, 2018; Lee et al, 2016; Montanaro et al, 2005; Valenzuela et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Diet, Plasma, Erythrocytes, and Spermatozoa Fatty Acid Composition Changes in Young Vegan Men

Chamorro

González

Aliaga

et al. 2020

Lipids

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There has been increasing interest in vegan diets, but how this dietary pattern regulates tissue fatty acids (FA), especially in men, is unclear. Our aim was to evaluate the effect of a vegan diet on plasma, erythrocyte, and spermatozoa FA composition in young men. Two groups consisting of 67 young (18-25 years old) men were studied. One group following an omnivore diet but did not consume fish, shellfish or other marine foods (control, n = 33), and another group following a vegan diet (vegan, n = 34) for at least 12 months were compared. Dietary intake was assessed via a food frequency questionnaire and a 24-h recall. FA composition was measured in plasma, erythrocyte phospholipids, and spermatozoa by gas-liquid chromatography. Compared to controls, the vegan group had higher reported intakes of carbohydrate, dietary fiber, vitamins (C, E, K, and folate), and minerals (copper, potassium) but lower intakes of cholesterol, trans FA, vitamins B 6 , D, and B 12 , and minerals (calcium, iron, and zinc). Vegan's reported a lower saturated FA and not arachidonic acid intake, both groups did not intake eicosapentaenoic acid and docosahexaenoic acid (DHA), but vegan's showed a higher alpha linolenic acid ALA intake. Vegans had higher plasma, erythrocyte phospholipid, and spermatozoa ALA, but lower levels of other n-3 polyunsaturated fatty acid (PUFA), especially DHA. Vegans were characterized by higher ALA, but lower levels of other n-3 PUFA, especially DHA in plasma, erythrocytes, and spermatozoids. The biological significance of these findings requires further study.

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“…Hepatic iron overload can be found in numerous chronic liver diseases [152]. Some animal and epidemiological studies have suggested that high iron levels may have a harmful impact on glucose and lipid metabolism [154][155][156]. It is noteworthy that iron overload attenuates the hepatic expression of Ppar-α, which is an important transcriptional factor that promotes lipid and lipoprotein metabolism [113].…”

Section: Ironmentioning

confidence: 99%

Trace Elements, PPARs, and Metabolic Syndrome

Shi

Zou

Shen

et al. 2020

IJMS

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Metabolic syndrome (MetS) is a constellation of metabolic derangements, including central obesity, insulin resistance, hypertension, glucose intolerance, and dyslipidemia. The pathogenesis of MetS has been intensively studied, and now many factors are recognized to contribute to the development of MetS. Among these, trace elements influence the structure of proteins, enzymes, and complex carbohydrates, and thus an imbalance in trace elements is an independent risk factor for MetS. The molecular link between trace elements and metabolic homeostasis has been established, and peroxisome proliferator-activated receptors (PPARs) have appeared as key regulators bridging these two elements. This is because on one hand, PPARs are actively involved in various metabolic processes, such as abdominal adiposity and insulin sensitivity, and on the other hand, PPARs sensitively respond to changes in trace elements. For example, an iron overload attenuates hepatic mRNA expression of Ppar-α; zinc supplementation is considered to recover the DNA-binding activity of PPAR-α, which is impaired in steatotic mouse liver; selenium administration downregulates mRNA expression of Ppar-γ, thereby improving lipid metabolism and oxidative status in the liver of high-fat diet (HFD)-fed mice. More importantly, PPARs' expression and activity are under the control of the circadian clock and show a robust 24 h rhythmicity, which might be the reasons for the side effects and the clinical limitations of trace elements targeting PPARs. Taken together, understanding the casual relationships among trace elements, PPARs' actions, and the pathogenesis of MetS is of great importance. Further studies are required to explore the chronopharmacological effects of trace elements on the diurnal oscillation of PPARs and the consequent development of MetS.

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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues

Cited by 42 publications

References 52 publications

Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

Diet, Plasma, Erythrocytes, and Spermatozoa Fatty Acid Composition Changes in Young Vegan Men

Trace Elements, PPARs, and Metabolic Syndrome

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