Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women,,,

Swain, James H.; Alekel, D. Lee; Dent, Sarah B.; Peterson, Charles T.; Reddy, Manju B.

doi:10.1093/ajcn/76.1.165

Cited by 48 publications

(38 citation statements)

References 32 publications

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“…In addition, our previous study also demonstrated that 40 g/day ISP for 24 weeks did not affect iron status in perimenopausal women (n = 69). 17 These results differ, however, from our subsequent 6-week study involving postmenopausal women (n = 15), which showed a significant decrease in Tf saturation (28%) and serum ferritin (30%), as well as a moderate reduction in serum iron (7%), in response to the consumption of 40 g/day ISP (40 g/d). 18 The discrepancy among these studies may be attributed to differences in iron status of subjects at baseline, in addition to the amount of soy protein intake and the duration of intervention.…”

contrasting

confidence: 85%

“…53 For example, the average serum ferritin concentration in the postmenopausal women was 65.4 ng/mL, 18 compared to 27.3 ng/ mL in our premenopausal women. Our current results from premenopausal women agree with those from the perimenopausal women, 17 but not from those of the postmenopausal 18 women, strongly supporting the hypothesis that subjects with low iron status have higher absorption than those with adequate iron status, particularly from foods with low iron bioavailability.…”

supporting

confidence: 75%

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The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

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Background: Soy foods have been substituted for meat in recent years because of proposed health benefits. Research indicates, however, that soy protein and phytate in soy products inhibit the absorption of divalent cations. Methods: Our study was primarily designed to determine the effect of consuming two to three servings per day of soy foods, providing *19 g protein and *36 mg isoflavones, on iron and zinc status in premenopausal women during a 10-weeks period. As secondary outcomes, we also tested the effect of soy foods on biochemical markers of bone and thyroid hormones. Nonsmoking women (18-28 years) without chronic disease, anemia, pregnancy, or irregular menstrual cycles were randomly assigned to either the soy food (SF, n = 31) or animal food (AF, n = 32) group. Blood and urine samples and 3-day dietary records were collected at baseline and postintervention. Results: At baseline, iron and zinc status, bone markers, and thyroid hormones were not different between groups. After intervention, no significant changes were observed in hemoglobin, transferrin saturation, serum iron, ferritin, or transferrin receptor (TFR) concentrations. Plasma zinc, but not serum alkaline phosphatase, significantly decreased in both groups ( -0.8 lmol/L).

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contrasting

confidence: 85%

supporting

confidence: 75%

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

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“…Note the signifi cant increase in total plasma testosterone (logarithmic; mean + SD). [20] , enhancing the expression of lipoprotein receptors [21] or (mostly valid for soy protein) decreasing oxidative stress, whether induced [22] or intrinsic [23] . These effects are more profound in diabetic patients [24] , but questionable in healthy perimenopausal women [25,26] .…”

Section: Discussionmentioning

confidence: 99%

Endocrine and Cognitive Effects of Short-Time Soybean Consumption in Women

Celec

Ostatníková

Cagánová³

et al. 2005

Gynecol Obstet Invest

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Background: Soy phytoestrogens are known to influence the hormonal status acting as partial estrogen agonists. Soy-derived food supplements are advised for hormone replacement therapy, prevention of atherosclerosis, age-related cognitive decline and even hormone-dependent cancer, although results from clinical studies are controversial. Whether increased soybean intake can affect the endocrine status and cognitive abilities is largely unknown. Aim: To observe the effects of 1 week of increased soybean intake on sex hormone levels and spatial cognitive abilities in women. Subjects and Methods: 16 young healthy female volunteers were asked to eat 900 g of soybeans within 1 week. Salivary testosterone (T), free and total plasma T, salivary and plasma estradiol (E) were measured by radioimmunoassay before and after the study period. Mental rotation (MR) and spatial visualization (SV) psychological tests were done at the days of sampling. Results: Soybean intake increased total plasma T levels (p < 0.02) while decreasing salivary T (p < 0.01) and not altering free plasma T levels. Salivary and plasma E levels were not changed. The results of MR and SV tests were improved after the study period. Conclusion: Short-time increased soybean intake alters the level of total plasma and salivary T and improves spatial cognition in women. Whether this effect is mediated by modulation of estrogen receptors, changes in sex hormone-binding globulin production or changes in activity of steroid-competent enzymes needs further study.

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“…Long-chain polyunsaturated fatty acids (PUFA) are well-documented direct contributors to oxidative stress through increased lipid peroxidation [11,12]. Iron consumption is hypothesized to intensify oxidative stress in the colon by catalyzing the production of highly reactive hydroxyl radicals via the Haber-Weiss reaction [13]. Diet can also be an important source of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas

Goodman

Bostick

Dash

et al. 2008

Cancer Causes Control

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Despite compelling basic science evidence, the search for causal associations linking specific pro- and anti-oxidants to presumably oxidative stress-related neoplasms, such as colorectal adenoma, has produced inconsistent results. We developed an oxidative balance score (OBS) to characterize the pro-oxidant and anti-oxidant exposures of 2,305 participants in a case-control study of colorectal adenoma that used both endoscopy-confirmed and community controls. Twelve lifestyle medical and dietary factors with known pro- or anti-oxidant properties were considered. Each high anti-oxidant exposure and low pro-oxidant exposure was awarded one or two points depending on the level of exposure, and the points for each OBS component were summed. We observed a significant inverse association between OBS (continuous variable) and colorectal adenoma in the analyses with either community, or endoscopy controls (each p-trend < 0.01). When the OBS was treated as an ordinal variable and a score of

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Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women,,,

Abstract: SPI intake had no significant effect on iron status, but our results suggest that dietary soy protein and low iron stores may protect perimenopausal women from oxidative stress.

Cited by 48 publications

References 32 publications

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Endocrine and Cognitive Effects of Short-Time Soybean Consumption in Women

A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas

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