Iron in Free Radical Reactions and Antioxidant Protection

Gutteridge, John M.C.

doi:10.1007/978-1-4757-2907-8_1

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…Transition metal ions like Cu + + and Fe + + play an important role as components of proteins essential for biological functions. However, these metals have also been implicated in the initiation of Haber-Weis and Fenton reactions where superoxide anions are transformed into the detrimental hydroxyl radicals in turn responsible for attack of the membrane polyunsatured fatty acids (Halliwell and Gutteridge, 1984;Gutteridge, 1998). The use of metal chelating agents may have therapeutic effect by reducing the oxidative burst and the consequent membrane lipid peroxidation (Gutteridge, 1998;Armstrong et al, 2001;Center, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…However, these metals have also been implicated in the initiation of Haber-Weis and Fenton reactions where superoxide anions are transformed into the detrimental hydroxyl radicals in turn responsible for attack of the membrane polyunsatured fatty acids (Halliwell and Gutteridge, 1984;Gutteridge, 1998). The use of metal chelating agents may have therapeutic effect by reducing the oxidative burst and the consequent membrane lipid peroxidation (Gutteridge, 1998;Armstrong et al, 2001;Center, 1999). Previous findings have shown that transition metals are implicated in the mediation of free radical production after CCl 4 administration in rats (Younes and Siegers, 1985;Mansour, 2000;Siegers et al, 1988;Tsokos-Kuhn, 1989).…”

Section: Discussionmentioning

confidence: 99%

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Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury

et al. 2004

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“…Chain-breaking antioxidants, also termed primary antioxidants, eliminate radical species, whereas preventative antioxidants (secondary antioxidants) obstruct radical formation . Antioxidants synthesized naturally include superoxide dismutase, catalases, peroxidases, GSH, urate, and ubiquinol …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Poly(ethylene glycol)−Glutathione Conjugate Self-Assembled Nanoparticles for Antioxidant Delivery

et al. 2008

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Functional oligomers based on glutathione (GSH) and poly(ethylene glycol) diacrylate (PEGDA) were synthesized via Michael addition. Well-defined, spherical nanoparticle self-assembly was confirmed via dynamic light scattering and transmission electron microscopy. In addition, a series of Michael addition oligomers containing GSH were prepared with various molecular weights of poly(ethylene glycol) (PEG). Thermal analysis indicated that the oligomers were thermally stable to approximately 160 degrees C, and the Tg increased as the PEG molecular weight increased. In addition, thiol-terminated PEG was synthesized and reacted with GSH to form disulfide-linked oligomers to probe potential antioxidant therapies. SH-SY5Y cells were utilized in cell culture experiments, and hydrogen peroxide induced oxidative stress on the cells. Disulfide-linked GSH oligomers were 100% effective at protecting SH-SY5Y cells from oxidative stress, whereas the Michael addition GSH oligomers did not offer protection.

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Characteristics of non-specific permeability and H + -ATPase inhibition induced in the plasma membrane of Nitella flexilis by excessive Cu 2+

Demidchik

Соколик

Yurin

2001

Planta

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Effects of Cu2+ on a non-specific conductance and H+-ATPase activity in the plasma membrane of the freshwater alga Nitella flexilis L. Agardh was studied using a conventional microelectrode voltage-clamp technique. We show that a Cu2+-induced increase in the non-specific conductance is related to the formation of pores in the plasma membrane. Pore formation is the result of unidentified chemical reactions, since the Q10 for the rate of increase of conductance over time was about 3. Various oxidants and antioxidants (10 mmol/l H2O2, 10 mmol/l ascorbate, 100 microg/ml superoxide dismutase, and 100 microg/ml catalase) did not alter Cu2+-induced changes in the plasma membrane conductance, suggesting that the effect of Cu2+ was unrelated to peroxidation of plasma-membrane lipids. In contrast, organic and inorganic Ca2+-channel antagonists (nifedipine, Zn2+, Cd2+, Fe2+, Ni2+) inhibited the Cu2+-induced non-specific conductance increase. This suggests that changes in Ca2+ influx underlie this effect of Cu2+. Decreasing the pH or the ionic strength of external solutions also inhibited the Cu2+-induced plasma-membrane conductance increase. Copper was also found to inhibit plasma-membrane H+-ATPase activity with half-maximal inhibition occurring at about 5-20 micromol/l and full inhibition at about 100-300 micromol/l. The Hill coefficient of Cu2+ inhibition of the H+-ATPase was close to two.

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Iron in Free Radical Reactions and Antioxidant Protection

Cited by 6 publications

References 59 publications

Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury

Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury

Synthesis and Characterization of Poly(ethylene glycol)−Glutathione Conjugate Self-Assembled Nanoparticles for Antioxidant Delivery

Characteristics of non-specific permeability and H + -ATPase inhibition induced in the plasma membrane of Nitella flexilis by excessive Cu 2+

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