Iron(III) complexes of bis (benzimidazol-2-yl) methyl) thiophene-2,5-dicarboxamide: Synthesis, spectral and oxidation of o-phenylenediamine

Tyagi, Nidhi; Mathur, Pavan

doi:10.1016/j.saa.2012.07.004

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…The enzyme mimetic activities of POMs were determined spectrophotometrically by measuring the formation of DAB from OPD at 450 nm (ε = 2.1 × 10 4 mM −1 cm −1 ) 44 or TMB + from TMB at 650 nm (ε = 3.9 × 10 4 mM −1 cm −1 ) 45 using UV-vis spectrophotometer in a 1 cm cuvette. Typically, the 480 μ L of TMB (1.5 mM in ethanol) or OPD solution (3.6 mM in water) was added into 2400 μ L different buffer solutions (NaH 2 PO 4 -citrate or Tris-HCl), followed by the addition of 60 μ L of POMs (10 mM) and 60 μ L of hydrogen peroxide (H 2 O 2 , 10 M).…”

Section: Methodsmentioning

confidence: 99%

The Intrinsic Enzyme Activities of the Classic Polyoxometalates

Zhang

Zhao

Tian

et al. 2019

Sci Rep

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The mimicking enzyme activities of eighteen classic POMs with different structures, Keggin (H3PW12O40, H4SiW12O40, H4GeW12O40, K4GeW12O40, H3PMo12O40, H4SiMo12O40 and Eu3PMo12O40), Wells-Dawson (H6P2Mo18O62, α-(NH4)6P2W18O62 and α-K6P2W18O62·14H2O), lacunary-Keggin (Na8H[α-PW9O34], Na10[α-SiW9O34], Na10[α-GeW9O34] and K8[γ-SiW10O36]), the transition-metal substituted-type (α-1,2,3-K6H[SiW9V3O34] and H5PMo10V2O40), sandwich-type (K10P2W18Fe4(H2O)2O68) and an isopolyoxotungstate (Na10H2W12O42) were screened and compared. The mechanisms and reaction conditions of POMs with mimicking enzyme-like activities were also analyzed. The results shown that the structures, the hybrid atoms, the coordination atoms, the substituted metal atoms, pH and substrate are the effect factors for the enzyme mimic activities of POM. Among the eighteen POMs, H3PW12O40, H4SiW12O40, H4GeW12O40, α-(NH4)6P2W18O62, α-K6P2W18O62·14H2O, Na8H[α-PW9O34], Na10[α-SiW9O34], Na10[α-GeW9O34], K8[γ-SiW10O36], K10P2W18Fe4(H2O)2O68 and Na10H2W12O42 had the peroxidase activities. Eu3PMo12O40, H3PMo12O40, H4SiMo12O40, α-1,2,3-K6H [SiW9V3O34], H6P2Mo18O62 and H5PMo10V2O40 showed the oxidase-like activities. K4GeW12O40 did not show the peroxidase and oxidase activities. The Na8H[α-PW9O34], Na10[α-SiW9O34] and Na10[α-GeW9O34] showed intrinsic enzyme activities at alkaline conditions, which were different from other type of POMs. The sandwich-type K10P2W18Fe4(H2O)2O68 displayed the strongest peroxidase activity, which is similar to natural horseradish peroxidase.

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Section: Methodsmentioning

confidence: 99%

The Intrinsic Enzyme Activities of the Classic Polyoxometalates

Zhang

Zhao

Tian

et al. 2019

Sci Rep

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“…A new band at 425-430 nm increases which confirms the formation of 2,3-diaminophenazine [12]. The concentration of product formed was calculated using the reported extinction coefficient of 2,3-diaminophenazine [12]. Absorbance versus wavelength plot is shown in fig.3(a).…”

Section: Epr Datamentioning

confidence: 93%

“…One ml of this reaction mixture is diluted by one ml of methanol and the absorption spectra of this solution were recorded with time in the range 300-1100 nm at room temperature, for a period of 40 minutes. A new band at 425-430 nm increases which confirms the formation of 2,3-diaminophenazine [12]. The concentration of product formed was calculated using the reported extinction coefficient of 2,3-diaminophenazine [12].…”

Section: Epr Datamentioning

confidence: 97%

“…Since reports of aerobic oxidation of o-phenylenediamine using copper(II) complexes are scarce, therefore the present complexes are used to study the kinetics of aerobic oxidation of ophenylenediamine to 2,3-diaminophenazine. Earlier we have reported the oxidation of ophenylenediamine assisted by H 2 O 2 using a Fe(III) bis-benzimidazolyl diamide complex [12].…”

Section: Introductionmentioning

confidence: 99%

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Copper(II) complexes as catalyst for the aerobic oxidation of o-phenylenediamine to 2,3-diaminophenazine

Khattar

Yadav

Mathur

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…[ 35–37 ] To the best of our knowledge, there is a single report by iron complex. [ 38 ] In this work, we have used iron complexes as a functional model of phenoxazinone synthase which involves oxygen activation. To the best of our knowledge so far, iron complexes exhibiting simultaneously self‐activating oxidative nuclease, protease, and OAP oxidase activities were not reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Mononuclear iron(III) complexes derived from tridentate ligands containing non‐innocent phenolato donors: Self‐activated nuclease, protease, and phenoxazinone synthase activity studies

Maji

Rathi

Singh

et al. 2021

Applied Organom Chemis

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The tridentate ligands HPhimpH, OCH3PhimpH, CH3PhimpH, tBuPhimpH, and NO2PhimpH have been synthesized and characterized. These tridentate ligands having non‐innocent phenolato function, Npy and Nim donors upon deprotonation bind to iron(III) center resulting in a series of novel iron complexes, namely, [Fe(HPhimp)2](ClO4) (1), [Fe(OCH3Phimp)2](ClO4) (2), [Fe(CH3Phimp)2](ClO4) (3), [Fe(tBuPhimp)2](ClO4) (4), and [Fe(NO2Phimp)2](ClO4) (5). Complexes were characterized by elemental analysis, IR, and UV–visible, and electrospray ionization mass spectral (ESI–MS) studies. Molecular structure of complex 2 was determined by single‐crystal X‐ray diffraction study. Electrochemical studies depicted Fe(III)/Fe(II) couple in the range of −0.50 to −0.65 V versus Ag/AgCl. Theoretical calculation using density functional theory (DFT) was also performed to optimize the geometrical and structural parameters. Time‐dependent DFT (TD‐DFT) was also optimized to observe the electronic properties, and data obtained were found to be consistent with experimentally observed values. Representative complex 4 exhibited nuclease and protease activities in the absence of external agents. Complex 4 was found to cleave the DNA and protein via self‐activated mechanism. Complexes 1–5 were utilized to optimize oxidation of o‐aminophenol in methanol. Complexes were found to be efficient in the oxidation of o‐aminophenol. Kinetic experiments were also explored to gain better insight into the oxidation process.

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Iron(III) complexes of bis (benzimidazol-2-yl) methyl) thiophene-2,5-dicarboxamide: Synthesis, spectral and oxidation of o-phenylenediamine

Cited by 8 publications

References 35 publications

The Intrinsic Enzyme Activities of the Classic Polyoxometalates

The Intrinsic Enzyme Activities of the Classic Polyoxometalates

Copper(II) complexes as catalyst for the aerobic oxidation of o-phenylenediamine to 2,3-diaminophenazine

Mononuclear iron(III) complexes derived from tridentate ligands containing non‐innocent phenolato donors: Self‐activated nuclease, protease, and phenoxazinone synthase activity studies

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