Iron(III) chloride-catalyzed convenient one-pot synthesis of β-acetamido carbonyl compounds

Methyl Acetoacetate: A Useful Reagent in Multicomponent Reactions

“…11,12 These compounds are valuable building blocks for the preparation of 1,3-amino alcohols or b-amino acids, as well as for the synthesis of various bioactive molecules. …”

Efficient Synthesis of β-Acetamido Ketones by Silver(I) Triflate-Catalyzed Multicomponent Reactions

“…10 Recently, another new procedure for the formation of β-acetamido ketones through the MCRs of acetophenone, arylaldehyde, and acetyl chloride in acetonitrile has been developed. [11][12][13][14][15][16][17][18][19][20][21] This reaction has been extensively studied with the use of a variety of catalysts and reagents such as 20 and Amberlyst-15.…”

“…Although numerous methods for the synthesis of β-acetamido ketones have been reported, [11][12][13][14][15][16][17][18][19][20][21] there is still demand for simpler, less toxic, more effective, and milder catalysts. Our interest in developing a mild and efficient synthetic method that provides a variety of β-acetamido ketones has led us to looking into more convenient and safely usable catalysts.…”

Bromodimethylsulfonium Bromide Catalyzed Three‐Component Mannich‐Type Reactions

“…[12a] In continuation of our work on the development of new synthetic methodologies, [14] we sought to explore the advantages of this reagent further for other important transformations. Here we report a simple and effective methodology for onepot, three-component, Mannich-type reactions of aromatic aldehydes, aromatic amines, and enolizable ketones or diethyl malonates in the presence of BDMS as a catalyst as shown in Scheme 1.…”