Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging

Structure and Properties of Iron Oxide Nanoparticles Encapsulated by Phospholipids with Poly(ethylene glycol) Tails

“…Poly(ethylene glycol) (PEG) containing shells are proven to be biocompatible, well soluble in water, and suitable for biomedical applications. 10,22,23 The shell on the NP surface can be created using several methods: by adsorption or growth of polymer or block copolymer chains, 22,24 by formation of NPs in the presence ofpolymericsurfactants, 25 byattachmentoffunctionalligands, 23,[26][27][28] or by formation of hydrophobic bilayers of amphiphilic molecules with the hydrophobic NP coating (encapsulation into amphiphilic micelles). [29][30][31] In this article, we report structure and properties of iron oxide NPs synthesized by decomposition of iron oleates and coated with PEGylated phospholipids via encapsulation.…”

Magnetic Nanoparticles: Its Effect on Cellular Behaviour and Potential Applications

“…Polyethylene glycol (PEG)-modified, phospholipid micelles coating is favourable since this can results in satisfactory solubility and stability in aqueous solutions, well biocompatibility, and also with prolonged blood circulation time when they are delivered intravenously. The PEG can be modified for bioconjugation of various moieties such as antibody, oligonucleotides, and peptides and may allow for molecular specific intracellular targeting of specific proteins and nucleic acid (Gupta & Gupta, 2005;Kohler et al, 2004;Kumagai et al, 2007;Lee et al, 2006Lee et al, , 2007aMikhaylova et al, 2004;Nitin et al, 2004;Veiseh et al, 2005). PEG-coated MNP has the disadvantage such as limited binding sites available for further ligand binding (Gupta & Gupta, 2005), and the coating thickness can significantly affect their relaxivity (Laconte et al, 2007).…”

Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy

“…Among them, PEG is the most used chemical material, which confers on IO nanoparticles several important properties such as high solubility and stability in aqueous solutions, biocompatibility, and prolonged blood circulation time. More importantly, the functional groups of modifi ed PEG allow for bioconjugation of various ligands or therapeutic agents to IO nanoparticles (Kohler et al 2004;Mikhaylova et al 2004;Nitin et al 2004;Gupta and Gupta 2005;Veiseh et al 2005;Lee et al 2006Lee et al , 2007aKumagai et al 2007). However, PEG-coated IO nanoparticles may have limited binding sites available for further ligand binding, since the number of functional groups on the surface of each IO nanoparticle is limited (Gupta and Gupta 2005).…”